The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems.

The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems.

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http://www.wikidata.org/entity/Q34433625

Q34433625

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Future pharmacological treatments for substance use disorders Neuropharmacology of alcohol addiction Glutamatergic substrates of drug addiction and alcoholism Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats The orexin system regulates alcohol-seeking in rats Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window Glutamatergic targets for new alcohol medications A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescents Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal.Cue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors.Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence Role of glutamate transporter 1 in the attenuation of alcohol intake.Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system.Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEP Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats.mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.(-)-2-oxa-4-aminobicylco[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine (MTEP) similarly attenuate stress-induced reinstatement of cocaine seeking.Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration.Current perspectives on the neurobiology of drug addiction: a focus on genetics and factors regulating gene expression.Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: implications for treatment.Differential modulation of ethanol-induced sedation and hypnosis by metabotropic glutamate receptor antagonists in C57BL/6J mice.Nonselective suppression of operant ethanol and sucrose self-administration by the mGluR7 positive allosteric modulator AMN082.Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions Review. Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders.Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress.Metabotropic glutamate receptor ligands as potential therapeutics for addiction The Effect of mGluR5 Antagonism During Binge Drinkingon Subsequent Ethanol Intake in C57BL/6J Mice: Sex- and Age-Induced Differences Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell.Glutamate plasticity woven through the progression to alcohol use disorder: a multi-circuit perspective.Investigational NMDA receptor modulators for depression.

P2860

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P2860

The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems.

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http://www.wikidata.org/entity/Q34433625

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2005 nî lūn-bûn

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2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2005 թվականի հուլիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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