Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair.
about
IgH chain class switch recombination: mechanism and regulationAdmixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody productionCernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesisUracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutationComplex regulation and function of activation-induced cytidine deaminase.An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex.Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination.Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination.Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversionDifferential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylaseActivation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombinationActivation-induced cytidine deaminase in antibody diversification and chromosome translocation.Novel and recurrent AID mutations underlie prevalent autosomal recessive form of HIGM in consanguineous patients.AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching.
P2860
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P2860
Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Impaired induction of DNA lesi ...... influences end-joining repair.
@ast
Impaired induction of DNA lesi ...... influences end-joining repair.
@en
Impaired induction of DNA lesi ...... influences end-joining repair.
@nl
type
label
Impaired induction of DNA lesi ...... influences end-joining repair.
@ast
Impaired induction of DNA lesi ...... influences end-joining repair.
@en
Impaired induction of DNA lesi ...... influences end-joining repair.
@nl
prefLabel
Impaired induction of DNA lesi ...... influences end-joining repair.
@ast
Impaired induction of DNA lesi ...... influences end-joining repair.
@en
Impaired induction of DNA lesi ...... influences end-joining repair.
@nl
P2093
P2860
P50
P356
P1476
Impaired induction of DNA lesi ...... influences end-joining repair.
@en
P2093
Hans D Ochs
Pauline Gardès
Sven Kracker
P2860
P304
22225-22230
P356
10.1073/PNAS.1012591108
P407
P577
2010-12-06T00:00:00Z