Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element
about
The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutationsQuantitative Trait Loci Identify Functional Noncoding Variation in CancerThe search for cis-regulatory driver mutations in cancer genomesEnabling functional genomics with genome engineeringThe biology of pediatric acute megakaryoblastic leukemiaRedefining ALL classification: toward detecting high-risk ALL and implementing precision medicineBrachyury, Foxa2 and the cis-Regulatory Origins of the NotochordEnhancer scanning to locate regulatory regions in genomic lociIntegrating next-generation sequencing into clinical oncology: strategies, promises and pitfallsTranscriptional Dynamics at Brain Enhancers: from Functional Specialization to NeurodegenerationEmerging concepts of epigenetic dysregulation in hematological malignanciesEpigenetic determinants of metastasisCross-species oncogenomics using zebrafish models of cancerThe Role of Histone Acetyltransferases in Normal and Malignant HematopoiesisdbSUPER: a database of super-enhancers in mouse and human genomeBCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesisAn oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.Archaic Adaptive Introgression in TBX15/WARS2.Exploiting Epigenetic Alterations in Prostate Cancer.The genomic landscape of core-binding factor acute myeloid leukemiasConvergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers.Applications of the CRISPR-Cas9 system in cancer biology.SEA: a super-enhancer archive.Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers.Role of non-coding sequence variants in cancer.MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.Models of human core transcriptional regulatory circuitries.Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets.Functional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR-Cas9-mediated mutagenesisc-Myb Binding Sites in Haematopoietic Chromatin LandscapesSignatures of accelerated somatic evolution in gene promoters in multiple cancer types.High-density P300 enhancers control cell state transitions.Identification of High-Impact cis-Regulatory Mutations Using Transcription Factor Specific Random Forest ModelsMotif signatures in stretch enhancers are enriched for disease-associated genetic variants.Mapping regulatory elements.Loss of Mll3 Catalytic Function Promotes Aberrant MyelopoiesisEGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.Tissue-specific tumorigenesis: context matters.
P2860
Q26753387-D7CB72EA-1563-4982-B72A-6989F97910F4Q26764745-28383E69-43F2-4D51-B19A-6072C70D7009Q26781886-C91C96A2-26FD-4747-940A-8ADA2896030FQ26782747-D83C7F45-A68B-47D8-9159-B02F300BA3B2Q26799478-60E690A1-862C-443E-A6F9-7473ED3EDD9BQ26864460-1E6453B0-D3BF-44D4-A37F-39EC4AE76789Q27309611-8BB6A00A-5CAD-4366-962A-FC1EB39E65E4Q27310315-75E43C90-5233-45A1-9C8B-715684ED7CE0Q28066709-B0673C2D-3123-444A-A442-F0DCB0DE13A3Q28067751-100A01AE-7725-4F3C-96F7-6EDE9A6F436BQ28074522-C775AA38-3866-4FD1-8125-3460E60EBC23Q28079377-EFC4C33A-2CAF-489C-AF65-F73FC3C2C71DQ28087440-4DA74B42-49D7-48C0-B023-4656FC56641FQ28088295-8540122D-5229-438B-9615-2A0CEAB9A219Q28603137-4815AB17-D335-4C03-A0EE-43B87BBF53E3Q28607483-7DA5E147-726E-46A5-AE4D-6D42AD1F6E2EQ30277644-48466C48-B565-4CF0-9A6C-69D2B4F75C76Q33681777-B44B5F80-A937-4792-A7B2-3DC3B4C52A55Q33755160-3232B905-20D3-4E4C-9493-0AB0D938FFF6Q33901968-EBA39BED-1697-4AB5-914B-835E5B5285D4Q34468271-6ADD5E99-F050-4CEC-8764-12A71CE28B61Q34479139-5F1A5A9B-DB33-4858-9DA2-53D78C57DA4EQ34502036-302E02B4-AFE7-4786-9A20-F2905D80EFAEQ34504751-846D5FFA-2638-4131-823B-663F23A3B023Q34509633-FD2BD9BC-9EBB-48E1-8FA3-4B73A4A944A9Q34511655-B10A96B0-9695-49B0-A4B6-BEEB86CF4BB3Q34512262-11E4AEA1-CD30-40B3-A3C5-793283371111Q34545220-DB8F737C-827C-4E14-91F9-E53ED0EDC78BQ35149666-33138108-3310-4609-8621-5872F0849024Q35656786-F9F49F7E-6822-4AC8-9E45-9E2B953877E4Q35711929-F1E8BB84-E81D-40FF-84C4-854C7E3EB618Q35770617-D1DDCEB3-066F-4EAC-A177-0029C740B922Q35834781-5C005462-49C4-4B53-AD2E-ED23B5C9AE31Q35840001-8BA235A5-E0A5-4C92-B526-090AD5D1742BQ35852366-A624E00E-67F4-403F-8929-FB841678FE49Q35915929-C2A68C8C-E114-4098-B52B-90C80BD244A0Q36127733-E9CF63BE-DD7A-402B-9134-C18E8162727FQ36172699-3AD2EDDA-BA86-4F89-8FFD-470F2C63D4F8Q36213758-F71D1C78-7EF8-46CB-920D-A3526A11C55AQ36296335-8801C6DC-6994-44CD-A871-FB08BF58263B
P2860
Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element
description
2014 nî lūn-bûn
@nan
2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Oncogene regulation. An oncoge ...... a noncoding intergenic element
@ast
Oncogene regulation. An oncoge ...... a noncoding intergenic element
@en
Oncogene regulation. An oncoge ...... a noncoding intergenic element
@nl
type
label
Oncogene regulation. An oncoge ...... a noncoding intergenic element
@ast
Oncogene regulation. An oncoge ...... a noncoding intergenic element
@en
Oncogene regulation. An oncoge ...... a noncoding intergenic element
@nl
prefLabel
Oncogene regulation. An oncoge ...... a noncoding intergenic element
@ast
Oncogene regulation. An oncoge ...... a noncoding intergenic element
@en
Oncogene regulation. An oncoge ...... a noncoding intergenic element
@nl
P2093
P50
P356
P1433
P1476
Oncogene regulation. An oncoge ...... a noncoding intergenic element
@en
P2093
A Thomas Look
Alejandro Gutierrez
Alla Berezovskaya
Julia Etchin
Lars Anders
Lee Lawton
Lewis B Silverman
Mignon L Loh
Stephen E Sallan
Stephen P Hunger
P2860
P304
P356
10.1126/SCIENCE.1259037
P407
P577
2014-11-13T00:00:00Z