about
Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomesParkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expressionSuper-enhancers in the control of cell identity and diseaseThe developmental potential of iPSCs is greatly influenced by reprogramming factor selectionTargeting transcription regulation in cancer with a covalent CDK7 inhibitorOncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic elementCDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitorConvergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers.CDK7-dependent transcriptional addiction in triple-negative breast cancer.Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.Models of human core transcriptional regulatory circuitries.Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions.Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitorsMultiple structural maintenance of chromosome complexes at transcriptional regulatory elements.Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas.Novel mechanism of positive versus negative regulation by thyroid hormone receptor β1 (TRβ1) identified by genome-wide profiling of binding sites in mouse liver.Small genomic insertions form enhancers that misregulate oncogenesGenome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3.A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancerTranscription factor trapping by RNA in gene regulatory elementsO-GlcNAcase Is an RNA Polymerase II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1β.Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in ErythropoiesisAPOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALLIntegrated genomic analyses of de novo pathways underlying atypical meningiomasThe long noncoding RNA Wisper controls cardiac fibrosis and remodeling.Erratum to: Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3.Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.YY1 Is a Structural Regulator of Enhancer-Promoter Loops.Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression.TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.High MITF Expression is Associated with Super-enhancers and Suppressed by CDK7 Inhibition in Melanoma.Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitryEWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing SarcomaCoactivator condensation at super-enhancers links phase separation and gene controlMYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer AmplificationRNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells
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description
researcher
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wetenschapper
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հետազոտող
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name
Brian J. Abraham
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Brian J. Abraham
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Brian J. Abraham
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Brian J. Abraham
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Brian J. Abraham
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type
label
Brian J. Abraham
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Brian J. Abraham
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Brian J. Abraham
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Brian J. Abraham
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Brian J. Abraham
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Brian Abraham
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Brian J. Abraham
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Brian J. Abraham
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Brian J. Abraham
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Brian J. Abraham
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Brian J. Abraham
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P1053
C-2230-2019
P106
P1153
55652299900
P21
P31
P496
0000-0001-8085-3027