Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.
about
Regulation of glucose homeostasis by GLP-1The class B G-protein-coupled GLP-1 receptor: an important target for the treatment of type-2 diabetes mellitusSystems-Level G Protein-Coupled Receptor Therapy Across a Neurodegenerative Continuum by the GLP-1 Receptor SystemOligomerization of Family B GPCRs: Exploration in Inter-Family Oligomer FormationGlucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic SuccessesTransmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsKey interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptorGenetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathwayPurification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptorActing on Hormone Receptors with Minimal Side Effect on Cell Proliferation: A Timely Challenge Illustrated with GLP-1R and GPERMinireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discoveryDimerization of visual pigments in vivo.Retinal pigment epithelial cells express a functional receptor for glucagon-like peptide-1 (GLP-1).Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor.Molecular Pharmacology of the Incretin Receptors.Regulation of CCR7-dependent cell migration through CCR7 homodimer formation.Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor.Receptor oligomerization: from early evidence to current understanding in class B GPCRs.Proinflammatory switch from Gαs to Gαi signaling by Glucagon-like peptide-1 receptor in murine splenic monocyte following burn injury.A kinetic view of GPCR allostery and biased agonism.Disruption of Rhodopsin Dimerization in Mouse Rod Photoreceptors by Synthetic Peptides Targeting Dimer Interface.
P2860
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P2860
Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Glucagon-like peptide-1 recept ...... fect small molecule allostery.
@ast
Glucagon-like peptide-1 recept ...... fect small molecule allostery.
@en
Glucagon-like peptide-1 recept ...... fect small molecule allostery.
@nl
type
label
Glucagon-like peptide-1 recept ...... fect small molecule allostery.
@ast
Glucagon-like peptide-1 recept ...... fect small molecule allostery.
@en
Glucagon-like peptide-1 recept ...... fect small molecule allostery.
@nl
prefLabel
Glucagon-like peptide-1 recept ...... fect small molecule allostery.
@ast
Glucagon-like peptide-1 recept ...... fect small molecule allostery.
@en
Glucagon-like peptide-1 recept ...... fect small molecule allostery.
@nl
P2093
P2860
P50
P356
P1476
Glucagon-like peptide-1 recept ...... ffect small molecule allostery
@en
P2093
Alicja M Ball
Bim Graham
Cassandra Koole
Delia I Pinon
Kaleeckal G Harikumar
Laurence J Miller
Maoqing Dong
P2860
P304
18607-18612
P356
10.1073/PNAS.1205227109
P407
P577
2012-10-22T00:00:00Z