Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase). - Wikidata - wikimedia - TriplyDB

Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase).

Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase).

http://www.wikidata.org/entity/Q34469930

about

Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation Acute inhibition of selected membrane-proximal mouse T cell receptor signaling by mitochondrial antagonists Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin The Open Form Inducer Approach for Structure-Based Drug Design.The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria.Mutation of the heme axial ligand of Escherichia coli succinate-quinone reductase: implications for heme ligation in mitochondrial complex II from yeast An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays Mitochondrial ROS Metabolism: 10 Years Later.Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine.Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate.Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria.The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels Mitochondrial diaphorases as NAD⁺ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition.Electron-transfer pathways in the heme and quinone-binding domain of complex II (succinate dehydrogenase).Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death.Mitochondria as a pharmacological target: magnum overview.Fungal natural products in research and development.Ecological functions of Trichoderma spp. and their secondary metabolites in the rhizosphere: interactions with plants.The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells.The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection.Inhibitory effects of respiration inhibitors on aflatoxin production.Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells.Differential metabolic responses to pluronic in MDR and non-MDR cells: a novel pathway for chemosensitization of drug resistant cancers.Bioisosteric Exchange of Csp3 -Chloro and Methyl Substituents: Synthesis and Initial Biological Studies of Atpenin A5 Analogues.Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production.Sartorypyrone D: a new NADH-fumarate reductase inhibitor produced by Neosartorya fischeri FO-5897.Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria.Expression of Saccharomyces cerevisiae Sdh3p and Sdh4p paralogs results in catalytically active succinate dehydrogenase isoenzymes.Crystallization of mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor flutolanil Respiratory Complex I in Bos taurus and Paracoccus denitrificans Pumps Four Protons across the Membrane for Every NADH Oxidized.

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Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase).

http://www.wikidata.org/entity/Q34469930

description

2003 nî lūn-bûn

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2003 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2003 թվականի հունվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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Atpenins, potent and specific ...... te-ubiquinone oxidoreductase).

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Atpenins, potent and specific ...... te-ubiquinone oxidoreductase).

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Atpenins, potent and specific ...... te-ubiquinone oxidoreductase).

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Atpenins, potent and specific ...... te-ubiquinone oxidoreductase).

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Atpenins, potent and specific ...... te-ubiquinone oxidoreductase).

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Atpenins, potent and specific ...... te-ubiquinone oxidoreductase).

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PNAS.0237315100

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Proceedings of the National Academy of Sciences of the United States of America

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Atpenins, potent and specific ...... te-ubiquinone oxidoreductase).

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Arihiro Osanai

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Hideaki Ui

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Hideto Miyoshi

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Hiroko Miyadera

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Hiroshi Tomoda

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Kazuro Shiomi

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Rokuro Masuma

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Yuichi Yamaguchi

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P2860

Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution

Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site

An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria.

The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma

Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans.

Isolation, characterization and sequence of a gene conferring resistance to the systemic fungicide carboxin from the maize smut pathogen, Ustilago maydis.

Role of complex II in anaerobic respiration of the parasite mitochondria from Ascaris suum and Plasmodium falciparum.

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473-477

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10960876

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12515859

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