The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels
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Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioningPhysiological consequences of complex II inhibition for aging, disease, and the mKATP channelPotent cardioprotective effect of the 4-anilinoquinazoline derivative PD153035: involvement of mitochondrial K(ATP) channel activationCardiomyocyte sulfonylurea receptor 2-KATP channel mediates cardioprotection and ST segment elevation.Direct activation of β-cell KATP channels with a novel xanthine derivative.The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria.SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts.A novel mitochondrial K(ATP) channel assay.Cardioprotective effects of PKG activation by soluble GC activator, BAY 60-2770, in ischemia-reperfusion-injured rat hearts.Cardiac mitochondria and reactive oxygen species generationSLO-2 is cytoprotective and contributes to mitochondrial potassium transport.A cell-based phenotypic assay to identify cardioprotective agentsSuccinate metabolism: a new therapeutic target for myocardial reperfusion injury.Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury.Redox regulation of the mitochondrial K(ATP) channel in cardioprotection.Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.Ischemic preconditioning: the role of mitochondria and agingMitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans.Hydrogen sulfide preconditioning protects against myocardial ischemia/reperfusion injury in rats through inhibition of endo/sarcoplasmic reticulum stressMitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival.Mitochondria as a drug target in ischemic heart disease and cardiomyopathyFatty acid nitroalkenes induce resistance to ischemic cardiac injury by modulating mitochondrial respiration at complex IIIsosteviol Sensitizes sarcKATP Channels towards Pinacidil and Potentiates Mitochondrial Uncoupling of Diazoxide in Guinea Pig Ventricular Myocytes.The mitochondrial K(ATP) channel--fact or fiction?LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism.Complex I and ATP synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondriaKir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioningChromophore-Assisted Light Inactivation of Mitochondrial Electron Transport Chain Complex II in Caenorhabditis elegans.Cardioprotection by metabolic shut-down and gradual wake-up.Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning.Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death.Mitochondrial channels: ion fluxes and more.Mechanisms involved in attenuated cardio-protective role of ischemic preconditioning in metabolic disorders.Mitochondrial potassium channels as pharmacological target for cardioprotective drugs.Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection.A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel.Novel thiazolidinedione mitoNEET ligand-1 acutely improves cardiac stem cell survival under oxidative stress.Bioisosteric Exchange of Csp3 -Chloro and Methyl Substituents: Synthesis and Initial Biological Studies of Atpenin A5 Analogues.Catalytic Asymmetric Synthesis of Ketene Heterodimer β-Lactones: Scope and Limitations.
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The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 26 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The complex II inhibitor atpen ...... of mitochondrial KATP channels
@en
The complex II inhibitor atpen ...... f mitochondrial KATP channels.
@nl
type
label
The complex II inhibitor atpen ...... of mitochondrial KATP channels
@en
The complex II inhibitor atpen ...... f mitochondrial KATP channels.
@nl
prefLabel
The complex II inhibitor atpen ...... of mitochondrial KATP channels
@en
The complex II inhibitor atpen ...... f mitochondrial KATP channels.
@nl
P2860
P1476
The complex II inhibitor atpen ...... of mitochondrial KATP channels
@en
P2093
Andrew P Wojtovich
Paul S Brookes
P2860
P2888
P304
P356
10.1007/S00395-009-0001-Y
P577
2009-02-26T00:00:00Z