Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication.
about
Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)Virological and cellular roles of the transcriptional coactivator LEDGF/p75Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityLEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integrationA tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivoImpact of Chromatin on HIV Replicationp12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomesStructural basis for high-affinity binding of LEDGF PWWP to mononucleosomesThe Gag cleavage product, p12, is a functional constituent of the murine leukemia virus pre-integration complexBiochemical characterization of novel retroviral integrase proteinsInteraction of HRP-2 isoforms with HDGF: chromatin binding of a specific heteromerRetroviral DNA IntegrationBiochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.Characterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression.DNA double strand break repair enzymes function at multiple steps in retroviral infection.HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase.Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.Mechanisms and inhibition of HIV integrationLEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINsMolecular mechanisms of retroviral integration site selection.Peptides that inhibit HIV-1 integrase by blocking its protein-protein interactions.Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.A prospective on drug abuse-associated epigenetics and HIV-1 replication.The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.HIV infection of non-dividing cells: a divisive problem.Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin proteinTranscriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration.Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targetingHIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modificationsHost Factors in Retroviral Integration and the Selection of Integration Target Sites.Clinical Use of Inhibitors of HIV-1 Integration: Problems and Prospects.A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin.RNA interference and antiviral therapy.Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.Integrase, LEDGF/p75 and HIV replication.Multimerization and DNA binding properties of INI1/hSNF5 and its functional significance.
P2860
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P2860
Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Biochemical and genetic analys ...... unction and HIV-1 replication.
@ast
Biochemical and genetic analys ...... unction and HIV-1 replication.
@en
Biochemical and genetic analys ...... ithelium-derived growth factor
@nl
type
label
Biochemical and genetic analys ...... unction and HIV-1 replication.
@ast
Biochemical and genetic analys ...... unction and HIV-1 replication.
@en
Biochemical and genetic analys ...... ithelium-derived growth factor
@nl
prefLabel
Biochemical and genetic analys ...... unction and HIV-1 replication.
@ast
Biochemical and genetic analys ...... unction and HIV-1 replication.
@en
Biochemical and genetic analys ...... ithelium-derived growth factor
@nl
P2093
P1433
P1476
Biochemical and genetic analys ...... unction and HIV-1 replication.
@en
P2093
Alan Engelman
Eric Devroe
Fanny Turlure
Nick Vandegraaff
P304
P356
10.1016/J.VIROL.2005.11.022
P407
P577
2005-12-09T00:00:00Z