Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage. - Wikidata - wikimedia - TriplyDB

Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.

Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.

http://www.wikidata.org/entity/Q34479835

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Role of the UPS in Liddle syndrome Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)Ubiquitylation and control of renal Na+ balance and blood pressure ENaC/DEG in Tumor Development and Progression Regulation and dysregulation of epithelial Na+ channels Nedd4-2 induces endocytosis and degradation of proteolytically cleaved epithelial Na+ channels A segment of gamma ENaC mediates elastase activation of Na+ transport Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis.Regulation of sodium transport by ENaC in the kidney Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel.Epithelial Na+ channel (ENaC), hormones, and hypertension.Regulation of the epithelial sodium channel (ENaC) by membrane trafficking Role of epithelial sodium channels and their regulators in hypertension.Cys palmitoylation of the beta subunit modulates gating of the epithelial sodium channel Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways Molecular mechanism of constitutive endocytosis of Acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death.A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation Intracellular ubiquitylation of the epithelial Na+ channel controls extracellular proteolytic channel activation via conformational change.Oxygen regulation of the epithelial Na channel in the collecting duct Genetic screening of SCNN1B and SCNN1G genes in early-onset hypertensive patients helps to identify Liddle syndrome.Validation and optimization of novel high-throughput assays for human epithelial sodium channels.ENaC structure and function in the wake of a resolved structure of a family member.Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites.Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site Hsp70 promotes epithelial sodium channel functional expression by increasing its association with coat complex II and its exit from endoplasmic reticulum.Acute downregulation of ENaC by EGF involves the PY motif and putative ERK phosphorylation site.Coupling of epithelial Na+ and Cl- channels by direct and indirect activation by serine proteases.Ubiquitin-specific peptidase 8 (USP8) regulates endosomal trafficking of the epithelial Na+ channel Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis.Heritable forms of hypertension.Deubiquitylation regulates activation and proteolytic cleavage of ENaC Extracellular protons regulate human ENaC by modulating Na+ self-inhibition SGK1 regulation by miR-466g in cortical collecting duct cells.Regulation of the epithelial sodium channel by membrane trafficking.SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms AMP-Activated Protein Kinase Attenuates High Salt-Induced Activation of Epithelial Sodium Channels (ENaC) in Human Umbilical Vein Endothelial Cells.Hsc70 negatively regulates epithelial sodium channel trafficking at multiple sites in epithelial cells.

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Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.

http://www.wikidata.org/entity/Q34479835

description

2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2006 թվականի փետրվարին հրատարակված գիտական հոդված

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2006年の論文

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Liddle's syndrome mutations in ...... sion and proteolytic cleavage.

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Liddle's syndrome mutations in ...... sion and proteolytic cleavage.

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Liddle's syndrome mutations in ...... sion and proteolytic cleavage.

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Diane R Olson

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Kristin K Knight

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Peter M Snyder

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Ruifeng Zhou

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P2860

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel

Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome

Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach

Cloning, expression, and tissue distribution of a human amiloride-sensitive Na+ channel

Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel

Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.

A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system.

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