Deubiquitylation regulates activation and proteolytic cleavage of ENaC
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Ubiquitylation and control of renal Na+ balance and blood pressureUSP2-45 Is a Circadian Clock Output Effector Regulating Calcium Absorption at the Post-Translational LevelUrinary Proteolytic Activation of Renal Epithelial Na+ Channels in Chronic Heart Failure.Alveolar epithelial CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption.Regulation of sodium transport by ENaC in the kidneyThe N-terminal domain allosterically regulates cleavage and activation of the epithelial sodium channel.Cys palmitoylation of the beta subunit modulates gating of the epithelial sodium channelUbiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertensionIntracellular ubiquitylation of the epithelial Na+ channel controls extracellular proteolytic channel activation via conformational change.Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.Direct interactions between ENaC gamma subunit and ClCN2 in cystic fibrosis epithelial cells.TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage siteUbiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels.Feedback inhibition of ENaC: acute and chronic mechanismsUSP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signalsUbiquitin-specific peptidase 8 (USP8) regulates endosomal trafficking of the epithelial Na+ channelMechanism of action of novel lung edema therapeutic AP301 by activation of the epithelial sodium channel.The delta-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation.Endosomal transport via ubiquitinationDynamic of ion channel expression at the plasma membrane of cardiomyocytes.Molecular physiology of the medullary collecting duct.TNF Lectin-Like Domain Restores Epithelial Sodium Channel Function in Frameshift Mutants Associated with Pseudohypoaldosteronism Type 1BCell surface turnover of the glutamate transporter GLT-1 is mediated by ubiquitination/deubiquitination.The neuronal-specific SGK1.1 kinase regulates {delta}-epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling.Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC.Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure.WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter.
P2860
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P2860
Deubiquitylation regulates activation and proteolytic cleavage of ENaC
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Deubiquitylation regulates activation and proteolytic cleavage of ENaC
@en
type
label
Deubiquitylation regulates activation and proteolytic cleavage of ENaC
@en
prefLabel
Deubiquitylation regulates activation and proteolytic cleavage of ENaC
@en
P2093
P2860
P356
P1476
Deubiquitylation regulates activation and proteolytic cleavage of ENaC
@en
P2093
Dorothée Ruffieux-Daidié
François Verrey
Olivier Poirot
Olivier Staub
Sheerazed Boulkroun
Stephan Kellenberger
P2860
P304
P356
10.1681/ASN.2007101130
P577
2008-08-13T00:00:00Z