Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor.
about
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαMolecular insights into the membrane-associated phosphatidylinositol 4-kinase IIαThe crystal structure of the phosphatidylinositol 4-kinase IIαPhosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase ItchPhosphoinositides: tiny lipids with giant impact on cell regulationLipid kinases as therapeutic targets for chronic painPtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes.Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphateArf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism.The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor designEmerging roles of PtdIns(4,5)P2--beyond the plasma membraneSac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platformsCinderella story: PI4P goes from precursor to key signaling moleculePhosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome trafficImage-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerizationLoss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axonsType II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in DrosophilaA novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi.Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current.BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behaviorEffect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma.A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking.Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα as anti-tumor strategy.PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation.Endosomal sorting of VAMP3 is regulated by PI4K2A.Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase.Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the golgi apparatus requires phosphatidylinositol 4-kinase IIα.Stabilization of phosphatidylinositol 4-kinase type IIbeta by interaction with Hsp90Palmitoylation controls the catalytic activity and subcellular distribution of phosphatidylinositol 4-kinase II{alpha}Signaling at the Golgi.Phosphoinositide signaling: new tools and insights.A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell typesPhosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis.CDP-diacylglycerol phospholipid synthesis in detergent-soluble, non-raft, membrane microdomains of the endoplasmic reticulumPhosphoinositides and vesicular membrane trafficPhosphatidylinositol 4-kinase IIα is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent mannerRapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cellsMolecular brightness analysis reveals phosphatidylinositol 4-Kinase IIβ association with clathrin-coated vesicles in living cells.Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha.
P2860
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P2860
Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Phosphatidylinositol 4-kinase ...... gradation of the EGF receptor.
@ast
Phosphatidylinositol 4-kinase ...... gradation of the EGF receptor.
@en
Phosphatidylinositol 4-kinase ...... gradation of the EGF receptor.
@nl
type
label
Phosphatidylinositol 4-kinase ...... gradation of the EGF receptor.
@ast
Phosphatidylinositol 4-kinase ...... gradation of the EGF receptor.
@en
Phosphatidylinositol 4-kinase ...... gradation of the EGF receptor.
@nl
prefLabel
Phosphatidylinositol 4-kinase ...... gradation of the EGF receptor.
@ast
Phosphatidylinositol 4-kinase ...... gradation of the EGF receptor.
@en
Phosphatidylinositol 4-kinase ...... gradation of the EGF receptor.
@nl
P2093
P50
P356
P1476
Phosphatidylinositol 4-kinase ...... gradation of the EGF receptor.
@en
P2093
Fedor Berditchevski
Mark G Waugh
Shane Minogue
P304
P356
10.1242/JCS.02752
P407
P577
2006-02-01T00:00:00Z