Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis.
about
RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory functionCharacterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteinsInsig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteinsThree mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesisCombined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genesCholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphilesDual functions of Insig proteins in cholesterol homeostasisCDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in DrosophilaUsing Sterol Substitution to Probe the Role of Membrane Domains in Membrane Functions.Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms.A role for sterol levels in oxygen sensing in Saccharomyces cerevisiae.Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and InsigsMembrane topology of human insig-1, a protein regulator of lipid synthesisIsolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHepatic proprotein convertases modulate HDL metabolismMaintaining cholesterol homeostasis: sterol regulatory element-binding proteinsSREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverEffects of fish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory element-binding proteins in the liver of laying hens.Side-chain oxysterols: from cells to membranes to molecules.Tumor-suppressive effects of CDK8 in endometrial cancer cells.The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.High fat feeding induces hepatic fatty acid elongation in mice.POSSIBLE REGULATION OF LDL-RECEPTOR BY NARINGENIN IN HEPG2 HEPATOMA CELL LINE.Sterol regulatory element-binding proteins are regulators of the NIS gene in thyroid cells.Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP.Activation of sterol regulatory element binding proteins in the absence of Scap in Drosophila melanogaster.Dual roles for cholesterol in mammalian cellsScientific side trips: six excursions from the beaten path.Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 gene and risk of knee osteoarthritis in a Chinese Han population.Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.Reverse genetics approaches to combat pathogenic arenavirusesOther ways to skin a cat: activating SREBP without Scap.Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis.Intersection of the unfolded protein response and hepatic lipid metabolismEffects of Long-Term Supplementation of Blue-Green Algae on Lipid Metabolism in C57BL/6J mice.Sterol regulatory element-binding proteins are regulators of the rat thyroid peroxidase gene in thyroid cells.SREBPs: transcriptional mediators of lipid homeostasis.Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis.
P2860
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P2860
Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Mutant mammalian cells as tool ...... regulation of lipid synthesis.
@ast
Mutant mammalian cells as tool ...... regulation of lipid synthesis.
@en
Mutant mammalian cells as tool ...... regulation of lipid synthesis.
@nl
type
label
Mutant mammalian cells as tool ...... regulation of lipid synthesis.
@ast
Mutant mammalian cells as tool ...... regulation of lipid synthesis.
@en
Mutant mammalian cells as tool ...... regulation of lipid synthesis.
@nl
prefLabel
Mutant mammalian cells as tool ...... regulation of lipid synthesis.
@ast
Mutant mammalian cells as tool ...... regulation of lipid synthesis.
@en
Mutant mammalian cells as tool ...... regulation of lipid synthesis.
@nl
P356
P1476
Mutant mammalian cells as tool ...... regulation of lipid synthesis.
@en
P2093
Michael S Brown
Robert B Rawson
P304
P356
10.1006/ABBI.2001.2615
P407
P577
2002-01-01T00:00:00Z