Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.
about
P1343
A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradationLKB1 associates with Brg1 and is necessary for Brg1-induced growth arrestA role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndromeUncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAFLKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.Tumour suppressor genes.Genetics of familial and sporadic melanoma.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.LKB1, a protein kinase regulating cell proliferation and polarity.Genetic profiling of colon cancer.LKB1 preserves genome integrity by stimulating BRCA1 expression.Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancersFindings from the Peutz-Jeghers syndrome registry of uruguay.5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer.The differential diagnosis of familial lentiginosis syndromesFrequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer.LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanomaOncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.LKB1; linking cell structure and tumor suppression.Dysregulation of mTOR activity through LKB1 inactivation.Rewiring cell polarity signaling in cancer.Resveratrol-downregulated phosphorylated liver kinase B1 is involved in senescence of acute myeloid leukemia stem cells.Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants Through Conformational Sampling Approach.A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinomaIgnoring matrix boundaries when the LKB1 master kinase is gone.KinMutBase: a registry of disease-causing mutations in protein kinase domains.Gastrointestinal diseases and their oro-dental manifestations: Part 4: Peutz-Jeghers syndrome.LKB1 mutations and their correlation with LKB1 and Rheb expression in bladder cancer.Lkb1 deletion in murine B lymphocytes promotes cell death and cancer.[Advances of LKB1-AMPK-mTOR Signaling Pathway in Tumor].New susceptibility loci for cutaneous melanoma risk and progression revealed using a porcine model.Melanocytic Naevi and Melanoma
P2860
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P2860
Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.
@ast
Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.
@en
Somatic mutations in the Peutz-Jeghers
@nl
type
label
Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.
@ast
Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.
@en
Somatic mutations in the Peutz-Jeghers
@nl
prefLabel
Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.
@ast
Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.
@en
Somatic mutations in the Peutz-Jeghers
@nl
P2093
P1476
Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.
@en
P2093
P304
P356
10.1046/J.1523-1747.1999.00551.X
P407
P4510
P577
1999-04-01T00:00:00Z
P5875
P6179
1023978507