Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation.
about
Alpha1-antichymotrypsin/Alzheimer's peptide Abeta(1-42) complex perturbs lipid metabolism and activates transcription factors PPARgamma and NFkappaB in human neuroblastoma (Kelly) cellsAcyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptideApolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitroSwapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidaseThe neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylationAlzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzymeCrystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localizationNeprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidasesRedox modulation of thimet oligopeptidase activity by hydrogen peroxideIdentification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches.Advances with RNA interference in Alzheimer's disease research.Recycling of the high valence States of heme proteins by cysteine residues of THIMET-oligopeptidase.Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice.Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.Flexibility in substrate recognition by thimet oligopeptidase as revealed by denaturation studies.Thimet oligopeptidase expression is differentially regulated in neuroendocrine and spermatid cell lines by transcription factor binding to SRY (sex-determining region Y), CAAT and CREB (cAMP-response-element-binding protein) promoter consensus seque14-3-3 epsilon modulates the stimulated secretion of endopeptidase 24.15.Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo.Expression and activity of thimet oligopeptidase (TOP) are modified in the hippocampus of subjects with temporal lobe epilepsy (TLE).
P2860
Q24292273-CD8F0FD7-51DD-4B77-8588-44962B9A9A08Q24293938-F58E0223-C87F-4523-B4C3-5D2CC75723B4Q24321663-84856D85-9092-4805-B67C-029D8A8F2359Q27643647-5D973A99-7EED-4ABC-8622-E6BBE92E5FB6Q28145199-701A18A4-F5CD-4344-ADE4-C95D653F9469Q28216644-E9F297F0-009A-48B6-933C-0CD4D24FD0C7Q28248182-B5AC072B-CBEA-41C0-9C30-443A21DA75F5Q28505860-6315CE03-366B-4ED6-89C8-CE4582657E24Q33862996-485DAD47-62A3-41A1-99D1-70D7A0358919Q34312807-A9CEB8F3-EBD9-49C9-8E2B-CBFEEC71C7E7Q34330911-93C217F1-BD86-446E-BA5C-3507CCF9B261Q35041150-1C78F4D6-2EA8-4D85-A9A1-A42B38CBAB29Q35829746-DBD4DC2A-C5F9-48B6-83E3-684804FF0210Q40808050-50642FD0-A3B5-48B5-9DE3-21FF7B6145B3Q42268455-EF4BBAE4-B1C8-40AE-ACB6-B9399AED91A9Q42936798-D083A391-7914-4CFC-ADD5-56D437C1646BQ43003253-241E5AF5-2E91-4D4D-AE4A-7128E4CFF58AQ46386496-D2E21CAF-1CBE-42FA-99AE-6C7A7F1BE4CCQ48557527-C67DED49-8F6A-4746-9483-84D2E9342008Q54214602-75DF2B40-9DE5-44F8-81C0-9CFD7234EB3C
P2860
Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Metalloendopeptidase EC 3.4.24 ...... loid-beta peptide degradation.
@ast
Metalloendopeptidase EC 3.4.24 ...... loid-beta peptide degradation.
@en
Metalloendopeptidase EC 3.4.24 ...... loid-beta peptide degradation.
@nl
type
label
Metalloendopeptidase EC 3.4.24 ...... loid-beta peptide degradation.
@ast
Metalloendopeptidase EC 3.4.24 ...... loid-beta peptide degradation.
@en
Metalloendopeptidase EC 3.4.24 ...... loid-beta peptide degradation.
@nl
prefLabel
Metalloendopeptidase EC 3.4.24 ...... loid-beta peptide degradation.
@ast
Metalloendopeptidase EC 3.4.24 ...... loid-beta peptide degradation.
@en
Metalloendopeptidase EC 3.4.24 ...... loid-beta peptide degradation.
@nl
P2093
P2860
P356
P1476
Metalloendopeptidase EC 3.4.24 ...... loid-beta peptide degradation.
@en
P2093
P2860
P304
18777-18784
P356
10.1074/JBC.274.26.18777
P407
P577
1999-06-01T00:00:00Z