Role of apoE/Abeta interactions in Alzheimer's disease: insights from transgenic mouse models.
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Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretionGenetically altering Abeta distribution from the brain to the vasculature ameliorates tau pathologyExpression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatmentModeling Alzheimer's disease: from past to futureAstroglia in dementia and Alzheimer's disease.Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficitsA nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade.Recent rodent models for Alzheimer's disease: clinical implications and basic research.Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer's disease.Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice.Engineering conformational destabilization into mouse apolipoprotein E. A model for a unique property of human apolipoprotein E4.Practical considerations for choosing a mouse model of Alzheimer's disease.Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation.GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity.APOE2 enhances neuroprotection against Alzheimer's disease through multiple molecular mechanisms.
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P2860
Role of apoE/Abeta interactions in Alzheimer's disease: insights from transgenic mouse models.
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2002 nî lūn-bûn
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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2002 թվականի հունվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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Role of apoE/Abeta interaction ...... from transgenic mouse models.
@ast
Role of apoE/Abeta interaction ...... from transgenic mouse models.
@en
Role of apoE/Abeta interaction ...... from transgenic mouse models.
@nl
type
label
Role of apoE/Abeta interaction ...... from transgenic mouse models.
@ast
Role of apoE/Abeta interaction ...... from transgenic mouse models.
@en
Role of apoE/Abeta interaction ...... from transgenic mouse models.
@nl
prefLabel
Role of apoE/Abeta interaction ...... from transgenic mouse models.
@ast
Role of apoE/Abeta interaction ...... from transgenic mouse models.
@en
Role of apoE/Abeta interaction ...... from transgenic mouse models.
@nl
P2093
P2860
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Role of apoE/Abeta interaction ...... from transgenic mouse models.
@en
P2093
P2860
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P304
P356
10.1038/SJ.MP.4001006
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2002-01-01T00:00:00Z