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HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

http://www.wikidata.org/entity/Q34529834

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The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles HIV type 1 Gag as a target for antiviral therapy Improved Bevirimat resistance prediction by combination of structural and sequence-based classifiers Pharmacological intervention of HIV-1 maturation The choreography of HIV-1 proteolytic processing and virion assembly Three-Dimensional Structural Characterization of HIV-1 Tethered to Human Cells.Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors.Protease cleavage leads to formation of mature trimer interface in HIV-1 capsid Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly Characterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative luciferase-Vpr packaging-based assay Structural and functional insights into the HIV-1 maturation inhibitor binding pocket Role of the SP2 domain and its proteolytic cleavage in HIV-1 structural maturation and infectivity Structure-Activity Relationships of the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PF-46396 Identification of potent maturation inhibitors against HIV-1 clade C Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles.Crystal structure of an HIV assembly and maturation switch.Zernike phase contrast cryo-electron tomography of whole bacterial cells.Maturation of the HIV-1 core by a non-diffusional phase transition.Analysis of human T-cell leukemia virus type 1 particles by using cryo-electron tomography.In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway.How HIV-1 Gag assembles in cells: Putting together pieces of the puzzle.Potential role for CA-SP in nucleating retroviral capsid maturation.Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity.A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid Viral life cycles captured in three-dimensions with electron microscopy tomography.Electron cryotomography studies of maturing HIV-1 particles reveal the assembly pathway of the viral core.A genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infectious virus Identification of an HIV-1 Mutation in Spacer Peptide 1 That Stabilizes the Immature CA-SP1 Lattice.Morphology and ultrastructure of retrovirus particles.The structural biology of HIV-1: mechanistic and therapeutic insights HIV-1 Capsid Inhibitors as Antiretroviral Agents A two-pronged structural analysis of retroviral maturation indicates that core formation proceeds by a disassembly-reassembly pathway rather than a displacive transition.Insights into the activity of maturation inhibitor PF-46396 on HIV-1 clade C New approaches for antiviral targeting of HIV assembly.Morphogenesis of the Infectious HIV-1 Virion.Human Immunodeficiency Virus Gag and protease: partners in resistance.HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat.Inhibition of HIV-1 Maturation via Small-Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein.Higher-order structure of the Rous sarcoma virus SP assembly domain.

P2860

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P2860

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

http://www.wikidata.org/entity/Q34529834

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

@ast

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

@en

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

@nl

type

label

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

@ast

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

@en

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

@nl

prefLabel

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

@ast

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

@en

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

@nl

P1433

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P2860

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P932

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P1433

Journal of Virology

P1476

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

@en

P2093

Alasdair C Steven

http://www.w3.org/2001/XMLSchema#string

Eric O Freed

http://www.w3.org/2001/XMLSchema#string

Paul W Keller

http://www.w3.org/2001/XMLSchema#string

P2860

Virus maturation as a new HIV-1 therapeutic target

The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid

Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production

Solution structure and dynamics of the Rous sarcoma virus capsid protein and comparison with capsid proteins of other retroviruses

Structure of full-length HIV-1 CA: a model for the mature capsid lattice

Structure of B-MLV capsid amino-terminal domain reveals key features of viral tropism, gag assembly and core formation

X-ray structures of the hexameric building block of the HIV capsid.

The Mechanism of HIV-1 Core Assembly: Insights from Three-Dimensional Reconstructions of Authentic Virions

Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein

Model for lentivirus capsid core assembly based on crystal dimers of EIAV p26

P304

1420-1428

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scholarly article

P356

10.1128/JVI.01926-10

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P407

P433

4

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P478

85

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P50

Catherine S Adamson

Bernard Heymann

P577

2010-11-24T00:00:00Z

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P698

21106735

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P932

3028903

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