Immunoglobulin kappa light chain variable region gene complex organization and immunoglobulin genes encoding anti-DNA autoantibodies in lupus mice.
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Role of Antibody Paratope Conformational Flexibility in the Manifestation of Molecular MimicryIndependently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequencesStructural characteristics of the variable regions of immunoglobulin genes encoding a pathogenic autoantibody in murine lupus.Primary structure of the variable region of monoclonal antibody 2B10, capable of inducing anti-idiotypic antibodies that recognize the C-terminal region of MSA-1 of Plasmodium falciparum.Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus.Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinationsBreakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.Light chain usage in anti-double-stranded DNA B cell subsets: role in cell fate determinationIsolated VH4 heavy chain variable regions bind DNA characterization of a recombinant antibody heavy chain library derived from patient(s) with active SLE.Complete sequence of a cDNA clone specifying sandbar shark immunoglobulin light chain: gene organization and implications for the evolution of light chains.Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus.Polyspecificity of Anti-lipid A Antibodies and Its Relevance to the Development of Autoimmunity.In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains.Abnormalities in the regulation of variable region genes that encode for antibodies to DNA may be a central factor in the pathogenesis of systemic lupus erythematosus.Role of Structure-Based Changes due to Somatic Mutation in Highly Homologous DNA-Binding and DNA-Hydrolyzing Autoantibodies Exemplified by A23P Substitution in the VH Domain.Single-Molecule Interactions of a Monoclonal Anti-DNA Antibody with DNA.The role of VL gene structural determinants in the fine specificity of anti-DNA antibodies.Antibody Epitope Specificity for dsDNA Phosphate Backbone Is an Intrinsic Property of the Heavy Chain Variable Germline Gene Segment Used
P2860
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P2860
Immunoglobulin kappa light chain variable region gene complex organization and immunoglobulin genes encoding anti-DNA autoantibodies in lupus mice.
description
1988 nî lūn-bûn
@nan
1988 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
Immunoglobulin kappa light cha ...... autoantibodies in lupus mice.
@ast
Immunoglobulin kappa light cha ...... autoantibodies in lupus mice.
@en
Immunoglobulin kappa light cha ...... autoantibodies in lupus mice.
@nl
type
label
Immunoglobulin kappa light cha ...... autoantibodies in lupus mice.
@ast
Immunoglobulin kappa light cha ...... autoantibodies in lupus mice.
@en
Immunoglobulin kappa light cha ...... autoantibodies in lupus mice.
@nl
prefLabel
Immunoglobulin kappa light cha ...... autoantibodies in lupus mice.
@ast
Immunoglobulin kappa light cha ...... autoantibodies in lupus mice.
@en
Immunoglobulin kappa light cha ...... autoantibodies in lupus mice.
@nl
P2093
P2860
P356
P1476
Immunoglobulin kappa light cha ...... autoantibodies in lupus mice.
@en
P2093
A N Theofilopoulos
D J Noonan
M A Duchosal
M E Johnson
R S Balderas
P2860
P304
P356
10.1172/JCI113689
P407
P577
1988-09-01T00:00:00Z