Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.
about
Caspase-activated DNase is required for maintenance of tolerance to lupus nuclear autoantigensPhenotypic characterization of autoreactive B cells--checkpoints of B cell tolerance in patients with systemic lupus erythematosusThe regulation and activation of lupus-associated B cells.Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell helpDual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice.Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB x NZW)F1 mice.A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune diseaseMRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells.Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice.Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice.Light chain usage in anti-double-stranded DNA B cell subsets: role in cell fate determinationRegulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle.Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions.Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cellsEfficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenesAutoimmunity to isomerized histone H2B in systemic lupus erythematosus.TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation.Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptorsRegulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice.Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes.Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.Mouse models of systemic lupus erythematosus reveal a complex pathogenesis.Phage display and bacterial expression of a recombinant Fab specific for Pseudomonas aeruginosa serotype O6 lipopolysaccharide.The regulation of murine lupus.Unique site of autoantibody production in Fas-deficient mice.Autoreactive responses to an environmental factor. 2. Phthalate-induced anti-DNA specificity is downregulated by autoreactive cytotoxic T cells.Effector and predisposing genes in murine lupus.Anti-DNA IgA autoantibodies are spontaneously generated in mouse Peyer's patches.Antigen-induced B cell apoptosis is independent of complement C4.The origin of anti-nuclear antibodies in bcl-2 transgenic mice.
P2860
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P2860
Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.
@ast
Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.
@en
type
label
Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.
@ast
Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.
@en
prefLabel
Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.
@ast
Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.
@en
P2093
P2860
P356
P1476
Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.
@en
P2093
P2860
P304
P356
10.1084/JEM.181.3.1157
P407
P577
1995-03-01T00:00:00Z