The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. - Wikidata - wikimedia - TriplyDB

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

http://www.wikidata.org/entity/Q34568200

about

Targeting LKB1 in cancer - exposing and exploiting vulnerabilities To breathe or not to breathe: the haematopoietic stem/progenitor cells dilemma Hypoxia and metabolic properties of hematopoietic stem cells Mitophagy in hematopoietic stem cells: the case for exploration Nutrient-sensing pathways and metabolic regulation in stem cells GSK-3 as potential target for therapeutic intervention in cancer TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms The emerging role of AMPK in the regulation of breathing and oxygen supply Progenitor cell dysfunctions underlie some diabetic complications Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development Aberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt RNA sequencing: advances, challenges and opportunities New Roles of Lkb1 in Regulating Adipose Tissue Development and Thermogenesis.The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89.TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway.PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo.Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.The Par3-like polarity protein Par3L is essential for mammary stem cell maintenance.Metabolic requirements for the maintenance of self-renewing stem cells.Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation.Signal transduction by mitochondrial oxidants.Metabolic regulation of redox status in stem cells.Anomalies in network bridges involved in bile Acid metabolism predict outcomes of colorectal cancer patients Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis.Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.AMPK at the nexus of energetics and aging.Stem cells and the impact of ROS signaling.Liver kinase B1 suppresses lipopolysaccharide-induced nuclear factor κB (NF-κB) activation in macrophages Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism LKB1 reduces ROS-mediated cell damage via activation of p38.A divergent role of the SIRT1-TopBP1 axis in regulating metabolic checkpoint and DNA damage checkpoint.The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

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P2860

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

http://www.wikidata.org/entity/Q34568200

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

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The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

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The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

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type

label

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

@ast

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

@en

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

@nl

prefLabel

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

@ast

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

@en

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

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The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

@en

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Alexandros Tzatsos

http://www.w3.org/2001/XMLSchema#string

Brinda Alagesan

http://www.w3.org/2001/XMLSchema#string

David T Scadden

http://www.w3.org/2001/XMLSchema#string

Fatih Ozsolak

http://www.w3.org/2001/XMLSchema#string

Judith Kim

http://www.w3.org/2001/XMLSchema#string

Nabeel Bardeesy

http://www.w3.org/2001/XMLSchema#string

Patrice Milos

http://www.w3.org/2001/XMLSchema#string

Peter J Park

http://www.w3.org/2001/XMLSchema#string

Rushdia Z Yusuf

http://www.w3.org/2001/XMLSchema#string

Stephanie Z Xie

http://www.w3.org/2001/XMLSchema#string

P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3

A ubiquitin-like system mediates protein lipidation.

The LKB1 tumor suppressor negatively regulates mTOR signaling

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

Inducible gene targeting in mice

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

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10.1038/NATURE09572

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7324

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468

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Nabeel Bardeesy

Francesco Ferrari

Orian S Shirihai

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2010-12-01T00:00:00Z

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49651540

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1049865214

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21124451

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3037591

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