Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. - Wikidata - wikimedia - TriplyDB

Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.

Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.

http://www.wikidata.org/entity/Q34574786

about

Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts Identifying and targeting tumor-initiating cells in the treatment of breast cancer FAK in cancer: mechanistic findings and clinical applications A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice Bi-directional signaling: extracellular matrix and integrin regulation of breast tumor progression Integrins in cancer: biological implications and therapeutic opportunities ASPP2 suppresses stem cell-like characteristics and chemoresistance by inhibiting the Src/FAK/Snail axis in hepatocellular carcinoma.VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer Non-thermal atmospheric pressure plasma inhibits thyroid papillary cancer cell invasion via cytoskeletal modulation, altered MMP-2/-9/uPA activity.CXCR1/2 pathways in paclitaxel-induced neuropathic pain Estrogen receptor-alpha promotes breast cancer cell motility and invasion via focal adhesion kinase and N-WASP.Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation.Preferential antitumor effect of the Src inhibitor dasatinib associated with a decreased proportion of aldehyde dehydrogenase 1-positive cells in breast cancer cells of the basal B subtype.Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis Integrin α2β1 in nonactivated conformation can induce focal adhesion kinase signaling Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells Blocking the formation of radiation-induced breast cancer stem cells.Quantification of epithelial cell differentiation in mammary glands and carcinomas from DMBA- and MNU-exposed rats.Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells.Oncogenes and tumor suppressor genes Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship Specific posttranslational modification regulates early events in mammary carcinoma formation.Post-translational glycoprotein modifications regulate colon cancer stem cells and colon adenoma progression in Apc(min/+) mice through altered Wnt receptor signaling.Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity.Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.APC selectively mediates response to chemotherapeutic agents in breast cancer.Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells.Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signaling.β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer.FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β.Endothelial FAK is required for tumour angiogenesis Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular Carcinoma

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P2860

Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.

http://www.wikidata.org/entity/Q34574786

description

2009 nî lūn-bûn

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2009 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2009 թվականի հունվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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name

Mammary epithelial-specific ab ...... cancer stem/progenitor cells.

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Mammary epithelial-specific ab ...... cancer stem/progenitor cells.

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Mammary epithelial-specific ab ...... cancer stem/progenitor cells.

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type

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Mammary epithelial-specific ab ...... cancer stem/progenitor cells.

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Mammary epithelial-specific ab ...... cancer stem/progenitor cells.

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Mammary epithelial-specific ab ...... cancer stem/progenitor cells.

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Mammary epithelial-specific ab ...... cancer stem/progenitor cells.

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Mammary epithelial-specific ab ...... cancer stem/progenitor cells.

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Mammary epithelial-specific ab ...... cancer stem/progenitor cells.

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0008-5472.CAN-08-3078

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Cancer Research

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Mammary epithelial-specific ab ...... cancer stem/progenitor cells.

@en

P2093

Chenran Wang

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Huaping Fan

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Huijun Wei

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Jun-Lin Guan

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Max S Wicha

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Ming Luo

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Suling Liu

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Tamas Nagy

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P2860

Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

Prospective identification of tumorigenic breast cancer cells

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

The Hedgehog response network: sensors, switches, and routers

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

Focal adhesion kinase: the first ten years

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466-474

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10.1158/0008-5472.CAN-08-3078

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2

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19147559

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3039129

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