PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. - Wikidata - wikimedia - TriplyDB

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.

http://www.wikidata.org/entity/Q34103928

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FAK in cancer: mechanistic findings and clinical applications Evolving Therapies and FAK Inhibitors for the Treatment of Cancer N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading.Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth.Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship Pyk2 promotes tumor progression in multiple myeloma Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth Target modulation by a kinase inhibitor engineered to induce a tandem blockade of the epidermal growth factor receptor (EGFR) and c-Src: the concept of type III combi-targeting Prostaglandins in cancer cell adhesion, migration, and invasion Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular Carcinoma Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition.Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression.Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities Synergism of FAK and tyrosine kinase inhibition in Ph+ B-ALL.Targeting the p53 pathway.A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation.Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy.Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function.Targeted inhibition of Src kinase with dasatinib blocks thyroid cancer growth and metastasis.Stromal Modulators of TGF-β in Cancer.Kinase inhibitors as potential agents in the treatment of multiple myeloma.Ambivalent role of pFAK-Y397 in serous ovarian cancer--a study of the OVCAD consortium.Focal adhesion kinase as a cancer therapy target.Influence of stress on extracellular matrix and integrin biology.Targeting FAK in human cancer: from finding to first clinical trials.RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.Meaningful prevention of breast cancer metastasis: candidate therapeutics, preclinical validation, and clinical trial concerns.Initial testing of VS-4718, a novel inhibitor of focal adhesion kinase (FAK), against pediatric tumor models by the Pediatric Preclinical Testing Program.Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-Kinase Inhibitors.Deciphering the effect of an oxovanadium(iv) complex with the flavonoid chrysin (VOChrys) on intracellular cell signalling pathways in an osteosarcoma cell line.Molecular Pathways: Endothelial Cell FAK-A Target for Cancer Treatment.Multiplexed high content screening reveals that cigarette smoke condensate-altered cell signaling pathways are accentuated through FAK inhibition in human bronchial cells.Angiogenesis biomarkers and their targeting ligands as potential targets for tumor angiogenesis.

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P2860

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.

http://www.wikidata.org/entity/Q34103928

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

PND-1186 FAK inhibitor selecti ...... hree-dimensional environments.

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PND-1186 FAK inhibitor selecti ...... hree-dimensional environments.

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PND-1186 FAK inhibitor selecti ...... hree-dimensional environments.

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type

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PND-1186 FAK inhibitor selecti ...... hree-dimensional environments.

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PND-1186 FAK inhibitor selecti ...... hree-dimensional environments.

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PND-1186 FAK inhibitor selecti ...... hree-dimensional environments.

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PND-1186 FAK inhibitor selecti ...... hree-dimensional environments.

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PND-1186 FAK inhibitor selecti ...... hree-dimensional environments.

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PND-1186 FAK inhibitor selecti ...... hree-dimensional environments.

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Cancer Biology and Therapy

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PND-1186 FAK inhibitor selecti ...... three-dimensional environments

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Ainhoa Mielgo

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Alok Tomar

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Cheni Kwok

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Colin Walsh

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Congxin Liang

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Connie Sun

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David D Schlaepfer

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Dwayne G Stupack

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Gerald McMahon

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Isabelle Tanjoni

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P2860

Integrin-regulated FAK-Src signaling in normal and cancer cells

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility

Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271

Signaling through focal adhesion kinase

p130Cas: a versatile scaffold in signaling networks

Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas

Focal adhesion kinase: in command and control of cell motility

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

Spheroid-based drug screen: considerations and practical approach

Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase.

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764-777

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scholarly article

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10.4161/CBT.9.10.11434

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10

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9

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42109257

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20234191

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2933317

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