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Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease

Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease

http://www.wikidata.org/entity/Q34577087

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ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection Neuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent Perspectives Multifunctional Abl kinases in health and disease RBR E3 ubiquitin ligases: new structures, new insights, new questions Mechanisms of altered redox regulation in neurodegenerative diseases--focus on S--glutathionylation Molecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunction Poly (ADP-ribose) in the pathogenesis of Parkinson's disease Protein Kinases and Parkinson's Disease c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson's disease model VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.Dynamic changes of the phosphoproteome in postmortem mouse brains.Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine Parkinson's disease model.Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13 Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease.Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).Parkinson's disease: a complex interplay of mitochondrial DNA alterations and oxidative stress.Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.Sulfhydration mediates neuroprotective actions of parkin Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration Nilotinib Effects in Parkinson's disease and Dementia with Lewy bodies.c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.Parkin plays a role in sporadic Parkinson's disease c-Abl in neurodegenerative disease Regulation of Parkin E3 ubiquitin ligase activity.Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.Oxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases?An emerging role of PARK2 in cancer.RBR E3-ligases at work Protein phosphorylation in neurodegeneration: friend or foe?

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Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease

http://www.wikidata.org/entity/Q34577087

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Novel regulation of parkin fun ...... ations for Parkinson's disease

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Novel regulation of parkin fun ...... ations for Parkinson's disease

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Novel regulation of parkin fun ...... ations for Parkinson's disease

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Novel regulation of parkin fun ...... ations for Parkinson's disease

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Novel regulation of parkin fun ...... ations for Parkinson's disease

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Novel regulation of parkin fun ...... ations for Parkinson's disease

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Novel regulation of parkin fun ...... ations for Parkinson's disease

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JNEUROSCI.1833-10.2011

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Journal of Neuroscience

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Novel regulation of parkin fun ...... ations for Parkinson's disease

@en

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Anthony J Valente

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Ayako Yamamoto

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James L Roberts

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Mona Bains

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Philipp J Kahle

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Qing Zhou

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Robert A Clark

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Senlin Li

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Syed F Ali

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Syed Z Imam

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P2860

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Dopamine covalently modifies and functionally inactivates parkin

Staging of brain pathology related to sporadic Parkinson's disease

Identification of far upstream element-binding protein-1 as an authentic Parkin substrate

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

Parkinson's disease: mechanisms and models

Molecular pathways of neurodegeneration in Parkinson's disease

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157-163

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scholarly article

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10.1523/JNEUROSCI.1833-10.2011

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1

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2011-01-01T00:00:00Z

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21209200

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Parkinson's disease

phosphorylation

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3039694

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