Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brains
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Total synthesis of bryostatin 7 via C-C bond-forming hydrogenationPostischemic PKC activation rescues retrograde and anterograde long-term memoryBryostatin improves survival and reduces ischemic brain injury in aged rats after acute ischemic strokeBryostatin-1 Restores Blood Brain Barrier Integrity following Blast-Induced Traumatic Brain InjuryDAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in strokeBryostatin Effects on Cognitive Function and PKCɛ in Alzheimer's Disease Phase IIa and Expanded Access Trials.Total synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent.Bryostatins: biological context and biotechnological prospects.Total synthesis of bryostatin 9Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone coreTranslating Nature's Library: The Bryostatins and Function-Oriented SynthesisChronic cerebral ischaemia forms new cholinergic mechanisms of learning and memory.Total synthesis of bryostatin 1The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.Increased BDNF protein expression after ischemic or PKC epsilon preconditioning promotes electrophysiologic changes that lead to neuroprotection.Improved protein kinase C affinity through final step diversification of a simplified salicylate-derived bryostatin analog scaffold.Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues.Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopySelective estrogen receptor modulators (SERMs) enhance neurogenesis and spine density following focal cerebral ischemiaCommon mechanisms of Alzheimer's disease and ischemic stroke: the role of protein kinase C in the progression of age-related neurodegeneration."Picolog," a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo.Total synthesis of bryostatins: the development of methodology for the atom-economic and stereoselective synthesis of the ring C subunit.DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortexPost ischemia intermittent hypoxia induces hippocampal neurogenesis and synaptic alterations and alleviates long-term memory impairment.Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death.Microbial natural products: molecular blueprints for antitumor drugs.Marinopyrroles: Unique Drug Discoveries Based on Marine Natural Products.Bryostatin and its synthetic analog, picolog rescue dermal fibroblasts from prolonged stress and contribute to survival and rejuvenation of human skin equivalents.Protein kinase C epsilon delays latency until anoxic depolarization through arc expression and GluR2 internalization.Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.Reduction of beta-amyloid levels by novel protein kinase C(epsilon) activators.Acyl Ghrelin Improves Synapse Recovery in an In Vitro Model of Postanoxic Encephalopathy.Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cδ and ε.Protein kinase C-regulated aβ production and clearance.Protein Kinase Cϵ (PKCϵ) Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95PKC Activation Counteracts ADAM10 Deficit in HuD-Silenced Neuroblastoma Cells.Concise synthesis of the bryostatin A-ring via consecutive C-C bond forming transfer hydrogenations.Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters.Potential Therapeutics for Vascular Cognitive Impairment and Dementia.2.45 GHz Microwave radiation impairs hippocampal learning and spatial memory: Involvement of local stress mechanism induced suppression of iGluR/ERK/CREB signaling.
P2860
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P2860
Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brains
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Poststroke neuronal rescue and ...... otein kinase C in adult brains
@ast
Poststroke neuronal rescue and ...... otein kinase C in adult brains
@en
Poststroke neuronal rescue and ...... otein kinase C in adult brains
@nl
type
label
Poststroke neuronal rescue and ...... otein kinase C in adult brains
@ast
Poststroke neuronal rescue and ...... otein kinase C in adult brains
@en
Poststroke neuronal rescue and ...... otein kinase C in adult brains
@nl
prefLabel
Poststroke neuronal rescue and ...... otein kinase C in adult brains
@ast
Poststroke neuronal rescue and ...... otein kinase C in adult brains
@en
Poststroke neuronal rescue and ...... otein kinase C in adult brains
@nl
P2093
P2860
P356
P1476
Poststroke neuronal rescue and ...... otein kinase C in adult brains
@en
P2093
Daniel L Alkon
Jarin Hongpaisan
Miao-Kun Sun
Thomas J Nelson
P2860
P304
13620-13625
P356
10.1073/PNAS.0805952105
P407
P577
2008-09-03T00:00:00Z