Functional analysis of point mutations in human flap endonuclease-1 active site
about
Conserved residues of human XPG protein important for nuclease activity and function in nucleotide excision repairHuman exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidanceThe RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activitiesMolecular interactions of human Exo1 with DNAMolecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshiiA conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organismsStructure of flap endonuclease 1 from the hyperthermophilic archaeonDesulfurococcus amylolyticusCoupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA DecayStructures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease FamilyThe structure of Escherichia coli ExoIX--implications for DNA binding and catalysis in flap endonucleasesThe crystal structure of flap endonuclease-1 from Methanococcus jannaschiiMutagenesis of conserved lysine residues in bacteriophage T5 5'-3' exonuclease suggests separate mechanisms of endo-and exonucleolytic cleavagePurification of Saccharomyces cerevisiae RNase H(70) and identification of the corresponding gene.Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complexCleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate.A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestineTrypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks.A general approach to break the concentration barrier in single-molecule imaging.Apoptosis-related functional features of the DNaseI-like family of nucleases.The protein components and mechanism of eukaryotic Okazaki fragment maturation.Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.Rad52/Rad59-dependent recombination as a means to rectify faulty Okazaki fragment processing.Methanococcus jannaschii flap endonuclease: expression, purification, and substrate requirementsPhosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity.Novel function of Rad27 (FEN-1) in restricting short-sequence recombination.Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavageInteractions of mutant and wild-type flap endonucleases with oligonucleotide substrates suggest an alternative model of DNA binding.The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.mRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: genetic and biochemical evidence that Vhs is a nuclease.Functional regulation of FEN1 nuclease and its link to cancerNovel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatinSingle-strand-specific nucleases.The kinetoplast structure-specific endonuclease I is related to the 5' exo/endonuclease domain of bacterial DNA polymerase I and colocalizes with the kinetoplast topoisomerase II and DNA polymerase beta during replicationNuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instabilityHigh risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant miceThe trans-autostimulatory activity of Rad27 suppresses dna2 defects in Okazaki fragment processing.Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonucleaseMultiplexed and microparticle-based analyses: quantitative tools for the large-scale analysis of biological systems.Flap endonuclease 1.
P2860
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P2860
Functional analysis of point mutations in human flap endonuclease-1 active site
description
1997 nî lūn-bûn
@nan
1997 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Functional analysis of point mutations in human flap endonuclease-1 active site
@ast
Functional analysis of point mutations in human flap endonuclease-1 active site
@en
Functional analysis of point mutations in human flap endonuclease-1 active site
@nl
type
label
Functional analysis of point mutations in human flap endonuclease-1 active site
@ast
Functional analysis of point mutations in human flap endonuclease-1 active site
@en
Functional analysis of point mutations in human flap endonuclease-1 active site
@nl
prefLabel
Functional analysis of point mutations in human flap endonuclease-1 active site
@ast
Functional analysis of point mutations in human flap endonuclease-1 active site
@en
Functional analysis of point mutations in human flap endonuclease-1 active site
@nl
P2093
P2860
P356
P1476
Functional analysis of point mutations in human flap endonuclease-1 active site
@en
P2093
P2860
P304
P356
10.1093/NAR/25.16.3332
P407
P577
1997-08-01T00:00:00Z