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Functional analysis of point mutations in human flap endonuclease-1 active site

Functional analysis of point mutations in human flap endonuclease-1 active site

http://www.wikidata.org/entity/Q34633807

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Conserved residues of human XPG protein important for nuclease activity and function in nucleotide excision repair Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities Molecular interactions of human Exo1 with DNA Molecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshii A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms Structure of flap endonuclease 1 from the hyperthermophilic archaeonDesulfurococcus amylolyticus Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family The structure of Escherichia coli ExoIX--implications for DNA binding and catalysis in flap endonucleases The crystal structure of flap endonuclease-1 from Methanococcus jannaschii Mutagenesis of conserved lysine residues in bacteriophage T5 5'-3' exonuclease suggests separate mechanisms of endo-and exonucleolytic cleavage Purification of Saccharomyces cerevisiae RNase H(70) and identification of the corresponding gene.Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate.A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks.A general approach to break the concentration barrier in single-molecule imaging.Apoptosis-related functional features of the DNaseI-like family of nucleases.The protein components and mechanism of eukaryotic Okazaki fragment maturation.Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.Rad52/Rad59-dependent recombination as a means to rectify faulty Okazaki fragment processing.Methanococcus jannaschii flap endonuclease: expression, purification, and substrate requirements Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity.Novel function of Rad27 (FEN-1) in restricting short-sequence recombination.Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage Interactions of mutant and wild-type flap endonucleases with oligonucleotide substrates suggest an alternative model of DNA binding.The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.mRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: genetic and biochemical evidence that Vhs is a nuclease.Functional regulation of FEN1 nuclease and its link to cancer Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin Single-strand-specific nucleases.The kinetoplast structure-specific endonuclease I is related to the 5' exo/endonuclease domain of bacterial DNA polymerase I and colocalizes with the kinetoplast topoisomerase II and DNA polymerase beta during replication Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice The trans-autostimulatory activity of Rad27 suppresses dna2 defects in Okazaki fragment processing.Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease Multiplexed and microparticle-based analyses: quantitative tools for the large-scale analysis of biological systems.Flap endonuclease 1.

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P2860

Functional analysis of point mutations in human flap endonuclease-1 active site

http://www.wikidata.org/entity/Q34633807

description

1997 nî lūn-bûn

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1997 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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1997 թվականի օգոստոսին հրատարակված գիտական հոդված

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1997年の論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年论文

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name

Functional analysis of point mutations in human flap endonuclease-1 active site

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Functional analysis of point mutations in human flap endonuclease-1 active site

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Functional analysis of point mutations in human flap endonuclease-1 active site

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type

label

Functional analysis of point mutations in human flap endonuclease-1 active site

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Functional analysis of point mutations in human flap endonuclease-1 active site

@en

Functional analysis of point mutations in human flap endonuclease-1 active site

@nl

prefLabel

Functional analysis of point mutations in human flap endonuclease-1 active site

@ast

Functional analysis of point mutations in human flap endonuclease-1 active site

@en

Functional analysis of point mutations in human flap endonuclease-1 active site

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Functional analysis of point mutations in human flap endonuclease-1 active site

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B Shen

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J P Nolan

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L A Sklar

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M S Park

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P2860

Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage

The characterization of a mammalian DNA structure-specific endonuclease

Essential amino acids for substrate binding and catalysis of human flap endonuclease 1

Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I

Evolutionary conservation of excision repair in Schizosaccharomyces pombe: evidence for a family of sequences related to the Saccharomyces cerevisiae RAD2 gene

Crystal structure of Thermus aquaticus DNA polymerase

A helical arch allowing single-stranded DNA to thread through T5 5'-exonuclease

Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins

Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair.

Discontinuous DNA synthesis by purified mammalian proteins

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