A membrane-embedded glutamate is required for ligand binding to the multidrug transporter EmrE
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Investigation of ligand binding to the multidrug resistance protein EmrE by isothermal titration calorimetryAnalyzing conformational changes in the transport cycle of EmrEX-ray structure of EmrE supports dual topology model.QacR−Cation Recognition Is Mediated by a Redundancy of Residues Capable of Charge Neutralization †Structures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket and Transcription Activation through Tyrosine ExpulsionA Single Acidic Residue Can Guide Binding Site Selection but Does Not Govern QacR Cationic-Drug AffinityA glutamate switch controls voltage-sensitive phosphatase functionCharacterization of the transport mechanism and permeant binding profile of the uridine permease Fui1p of Saccharomyces cerevisiae.Yeast Fex1p Is a Constitutively Expressed Fluoride Channel with Functional Asymmetry of Its Two Homologous DomainsMolecular properties of bacterial multidrug transportersFunctional analysis of novel multidrug transporters from human pathogensProtonation of a glutamate residue modulates the dynamics of the drug transporter EmrECompetition as a way of life for H(+)-coupled antiportersXenobiotic efflux in bacteria and fungi: a genomics updateAnalysis of a complete library of putative drug transporter genes in Escherichia coliEvidence for assembly of small multidrug resistance proteins by a "two-faced" transmembrane helix.Lipid bilayer composition influences small multidrug transporters.Outer membrane protein OmpW participates with small multidrug resistance protein member EmrE in quaternary cationic compound effluxFungal PDR transporters: Phylogeny, topology, motifs and function.EmrE dimerization depends on membrane environment.Topologically random insertion of EmrE supports a pathway for evolution of inverted repeats in ion-coupled transportersA common binding site for substrates and protons in EmrE, an ion-coupled multidrug transporter.Three-dimensional structure of the bacterial multidrug transporter EmrE shows it is an asymmetric homodimer.Structure, dynamics, and substrate-induced conformational changes of the multidrug transporter EmrE in liposomes.The drug/metabolite transporter superfamily.Antiparallel EmrE exports drugs by exchanging between asymmetric structuresStructure-function relationships of integral membrane proteins: membrane transporters vs channels.Crosslinking of membrane-embedded cysteines reveals contact points in the EmrE oligomer.A structural model of EmrE, a multi-drug transporter from Escherichia coli.Structure of the multidrug resistance efflux transporter EmrE from Escherichia coliOverexpression of mammalian integral membrane proteins for structural studies.Transforming a drug/H+ antiporter into a polyamine importer by a single mutation.The projection structure of EmrE, a proton-linked multidrug transporter from Escherichia coli, at 7 A resolutionMystery of multidrug transporters: the answer can be simple.Role of glutamate residues in substrate recognition by human MATE1 polyspecific H+/organic cation exporter.Structure and function of efflux pumps that confer resistance to drugsThe fast release of sticky protons: kinetics of substrate binding and proton release in a multidrug transporterIn vitro synthesis of fully functional EmrE, a multidrug transporter, and study of its oligomeric stateAsymmetric protonation of EmrE.Small multidrug resistance protein EmrE reduces host pH and osmotic tolerance to metabolic quaternary cation osmoprotectants.
P2860
Q24538014-2D90383D-38C5-40B2-BD57-EBE681790450Q26829989-6A30FF44-F21A-4037-8105-D215149AB0E5Q27649102-227825EB-CDC5-42CB-8422-2E1199902EAFQ27651116-EC0FE328-D273-4A16-884F-C7A8A326A9ECQ27651360-1EB950AA-3B6D-4AFC-BED2-C1E3B451E864Q27666705-76732148-2AD7-47C8-872C-B37CB8151D30Q27678935-96809E09-DE05-49D7-AE94-9D3EE7148EE9Q27937092-BABFB4D2-A451-4831-B040-DC4798BBD57AQ27938960-D1E8C72B-03D1-4F79-A580-88CC46F9C833Q28139376-5910C698-7EFD-4139-B9AB-01062148EABDQ28486828-8619DD62-864F-45FE-AF98-2D0FF7454838Q28604217-853ECDAE-0F78-4366-98F9-F3FB7E7931EAQ28657397-B1748107-64E0-4A30-BD8E-26CCA610FA73Q28834633-2EE78BDC-DF1E-4914-B2BA-B62B217BB216Q30724303-464D99A8-523F-4065-AB6E-B7C9B58758CBQ33238086-35765D1C-ECFB-4F63-97B1-05B7DFF9E173Q33387030-6DAD24D6-985D-4938-9F3E-96D143611D4FQ33570226-72656AB9-7967-4867-949E-CF5D074ED151Q33624643-81DCDB7E-B30F-49D7-81E0-303A2ECAB57EQ33771551-6D0A1C22-FCAF-4DDF-81A1-F96FC9FBE023Q33832720-DB357F36-7068-4C0C-87DB-58AA563AFE64Q33957164-A3950F23-B1F8-4156-82B5-ED2072801941Q34053453-0CC50614-3926-4D57-8548-242DD860CCFEQ34074515-1B425F05-A0FD-4E6F-86E1-AC5064392799Q34082606-56BCC209-7FB3-4468-A53E-4276E23E19A5Q34104584-594A5ACC-34B6-4F38-8E14-F4EFDB77D2F6Q34136300-3EF27BDF-3FD7-4CFE-BC69-60F790C90B54Q34155142-4F138149-0AB3-453D-A184-E6EE816E9AB6Q34185881-B4A2C3AD-4946-417F-9161-D64213E2CC70Q34299369-1EB6BD95-EF8C-46F2-97E5-C4FDBD8D5CF3Q34353228-0C9BB983-26E1-4163-BFFC-B922B355A436Q34433319-662C6926-1766-462A-A46C-8331C8279178Q34449290-5CB597AD-B908-44FB-814C-4A895AA27BC9Q34689868-06266C03-E023-4B79-822E-B8A93F2B2311Q34756325-10EFE02E-1FC7-4078-8CDF-11DA03ADC614Q35294152-A43CB95E-D49A-4AB5-8559-487980497F5AQ36156693-C008A60F-4325-4FB6-AA65-F2301D4C920EQ36159680-BFA13727-46EE-4CDE-B4EE-DC15E33F407DQ36333191-93C2C9A8-8AA9-421D-9428-BE40E77A368BQ36362667-BDA96395-0243-4DC7-AC30-B47471A04314
P2860
A membrane-embedded glutamate is required for ligand binding to the multidrug transporter EmrE
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
A membrane-embedded glutamate ...... the multidrug transporter EmrE
@ast
A membrane-embedded glutamate ...... the multidrug transporter EmrE
@en
A membrane-embedded glutamate ...... the multidrug transporter EmrE
@nl
type
label
A membrane-embedded glutamate ...... the multidrug transporter EmrE
@ast
A membrane-embedded glutamate ...... the multidrug transporter EmrE
@en
A membrane-embedded glutamate ...... the multidrug transporter EmrE
@nl
prefLabel
A membrane-embedded glutamate ...... the multidrug transporter EmrE
@ast
A membrane-embedded glutamate ...... the multidrug transporter EmrE
@en
A membrane-embedded glutamate ...... the multidrug transporter EmrE
@nl
P2860
P356
P1433
P1476
A membrane-embedded glutamate ...... the multidrug transporter EmrE
@en
P2093
S Schuldiner
P2860
P304
P356
10.1093/EMBOJ/19.2.234
P407
P577
2000-01-01T00:00:00Z