Talin-dependent integrin activation is required for fibrin clot retraction by platelets. - Wikidata - wikimedia - TriplyDB

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

http://www.wikidata.org/entity/Q34667580

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The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering Anti-thrombotic agents derived from snake venom proteins The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin αIIbβ3 to Initiate Outside-in Signaling in Platelets In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.Matrix adhesion polarizes heart progenitor induction in the invertebrate chordate Ciona intestinalis A directional switch of integrin signalling and a new anti-thrombotic strategy.Talins and kindlins: partners in integrin-mediated adhesion.Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.MALT1-ubiquitination triggers non-genomic NF-κB/IKK signaling upon platelet activation Blocking neutrophil integrin activation prevents ischemia-reperfusion injury Wdr1-Dependent Actin Reorganization in Platelet Activation.Blood clots are rapidly assembled hemodynamic sensors: flow arrest triggers intraluminal thrombus contraction The mechanism of kindlin-mediated activation of integrin αIIbβ3.Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation.A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding.Molecular mechanism of inside-out integrin regulation Mechanisms of talin-dependent integrin signaling and crosstalk The genetics of vascular incidents associated with second-generation antipsychotic administration.Talin and kindlin: the one-two punch in integrin activation.Integrin αIIbβ3 outside-in signaling.Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool.The Rap1-RIAM-talin axis of integrin activation and blood cell function Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes.Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression Effects of riboflavin and ultraviolet light treatment on platelet thrombus formation on collagen via integrin αIIbβ3 activation.Gα13 Switch Region 2 Relieves Talin Autoinhibition to Activate αIIbβ3 Integrin.An αIIb β3 antagonist prevents thrombosis without causing Fc receptor γ-chain IIa-mediated thrombocytopenia.Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance.Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development.

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P2860

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

http://www.wikidata.org/entity/Q34667580

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

@ast

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

@en

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

@nl

type

label

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

@ast

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

@en

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

@nl

prefLabel

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

@ast

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

@en

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

@nl

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BLOOD-2010-09-305433

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P1476

Talin-dependent integrin activation is required for fibrin clot retraction by platelets.

@en

P2093

Brian G Petrich

http://www.w3.org/2001/XMLSchema#string

David R Critchley

http://www.w3.org/2001/XMLSchema#string

Jacob R Haling

http://www.w3.org/2001/XMLSchema#string

Susan J Monkley

http://www.w3.org/2001/XMLSchema#string

P2860

Structural determinants of integrin recognition by talin

Structural basis of integrin activation by talin

Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

Talin binding to integrin beta tails: a final common step in integrin activation

Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.

The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation.

Disruption of the talin gene arrests mouse development at the gastrulation stage.

Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.

Biochemical and structural properties of the integrin-associated cytoskeletal protein talin.

The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation.

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1719-1722

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scholarly article

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10.1182/BLOOD-2010-09-305433

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5

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3056596

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