Disruption of the talin gene arrests mouse development at the gastrulation stage.
about
Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundleThe integrin-actin connection, an eternal love affairThe LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migrationIntegrin-based therapeutics: biological basis, clinical use and new drugsNovel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse StrainThe Structure of an Interdomain Complex That Regulates Talin ActivityCentral Region of Talin Has a Unique Fold That Binds Vinculin and ActinExtracellular rigidity sensing by talin isoform-specific mechanical linkagesMEK kinase activity is not necessary for Raf-1 function.Mice carrying a complete deletion of the talin2 coding sequence are viable and fertileTalin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.Integrins and integrin-associated proteins in the cardiac myocyte.Induction of focal adhesions and motility in Drosophila S2 cellsLocalization of an integrin binding site to the C terminus of talin.Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activationEvidence that talin alternative splice variants from Ciona intestinalis have different roles in cell adhesionStructural and mechanical functions of integrins.Talins and kindlins: partners in integrin-mediated adhesion.Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain.Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.Talin B is required for force transmission in morphogenesis of Dictyostelium.Talin-dependent integrin activation is required for fibrin clot retraction by platelets.Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.Progressive myopathy and defects in the maintenance of myotendinous junctions in mice that lack talin 1 in skeletal muscleRegulator of G-Protein Signalling-14 (RGS14) Regulates the Activation of αMβ2 Integrin during Phagocytosis.Talin 2 is a large and complex gene encoding multiple transcripts and protein isoformsVinculin and talin: focus on the myocardiumTalin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptorBlocking neutrophil integrin activation prevents ischemia-reperfusion injuryTalin determines the nanoscale architecture of focal adhesions.Cooperative Stimulation of Megakaryocytic Differentiation by Gfi1b Gene Targets Kindlin3 and Talin1Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafishOverlapping functions of the two talin homologues in DictyosteliumMechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3
P2860
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P2860
Disruption of the talin gene arrests mouse development at the gastrulation stage.
description
2000 nî lūn-bûn
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2000年論文
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Disruption of the talin gene arrests mouse development at the gastrulation stage.
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Disruption of the talin gene arrests mouse development at the gastrulation stage.
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Disruption of the talin gene arrests mouse development at the gastrulation stage.
@ast
Disruption of the talin gene arrests mouse development at the gastrulation stage.
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Disruption of the talin gene arrests mouse development at the gastrulation stage.
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Disruption of the talin gene arrests mouse development at the gastrulation stage.
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P2093
P2860
P1476
Disruption of the talin gene arrests mouse development at the gastrulation stage.
@en
P2093
Critchley DR
Giblett SM
Hemmings L
Kinston SJ
Monkley SJ
Pritchard CA
P2860
P304
P356
10.1002/1097-0177(2000)9999:9999<::AID-DVDY1079>3.0.CO;2-Y
P577
2000-12-01T00:00:00Z