Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
about
Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectivesPolycomb repressive complex's evolutionary conserved function: the role of EZH2 status and cellular backgroundTargeting EZH2 in cancerEZH2 in normal hematopoiesis and hematological malignanciesMutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomasEpigenomics of cancer - emerging new conceptsCombating the epigenome: epigenetic drugs against non-Hodgkin's lymphomaMechanisms of epigenetic regulation of leukemia onset and progressionHistone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and preventionCancer epigenetics drug discovery and development: the challenge of hitting the markChromatin signatures of cancerGain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic interventionPolycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic MutationsStructural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET DomainNew IDH1 mutant inhibitors for treatment of acute myeloid leukemiaStructural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genesEmerging concepts of epigenetic dysregulation in hematological malignanciesHistone lysine methyltransferases as anti-cancer targets for drug discoveryDiverse involvement of EZH2 in cancer epigeneticsSWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In VitroOccupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying PutEZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutationsRoles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem CellsDiffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2.Chromatin-regulating proteins as targets for cancer therapy.Polycomb and trithorax opposition in development and disease.Chromatin proteins and modifications as drug targets.Regulation and Role of EZH2 in CancerThe prognostic role of EZH2 expression in rectal cancer patients treated with neoadjuvant chemoradiotherapyEpigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells.A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferationWEE1 tyrosine kinase, a novel epigenetic modifierEZH2: biology, disease, and structure-based drug discoveryThe epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.
P2860
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P2860
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
description
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2012
@ast
im Februar 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 2012/02/21)
@nl
наукова стаття, опублікована в лютому 2012
@uk
مقالة علمية (نشرت في 21-2-2012)
@ar
name
Mutation of A677 in histone me ...... istone H3 on lysine 27 (H3K27)
@ast
Mutation of A677 in histone me ...... istone H3 on lysine 27 (H3K27)
@en
type
label
Mutation of A677 in histone me ...... istone H3 on lysine 27 (H3K27)
@ast
Mutation of A677 in histone me ...... istone H3 on lysine 27 (H3K27)
@en
prefLabel
Mutation of A677 in histone me ...... istone H3 on lysine 27 (H3K27)
@ast
Mutation of A677 in histone me ...... istone H3 on lysine 27 (H3K27)
@en
P2093
P2860
P921
P3181
P356
P1476
Mutation of A677 in histone me ...... istone H3 on lysine 27 (H3K27)
@en
P2093
Alan P. Graves
Anthony Della Pietra
Ashley M. Hughes
Benjamin Schwartz
Caretha L. Creasy
Edward Dul
Elsie Diaz
Gopinath Ganji
Heidi M. Ott
Kimberly E. Allen
P2860
P304
P3181
P356
10.1073/PNAS.1116418109
P407
P577
2012-02-21T00:00:00Z