HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress.
about
Role of endoplasmic reticulum stress in drug-induced toxicityA conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma CareXenobiotic perturbation of ER stress and the unfolded protein responseNovel delivery strategies for glioblastomaNelfinavir and other protease inhibitors in cancer: mechanisms involved in anticancer activityA High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell ModelsHIV protease inhibitors block oral epithelial cell DNA synthesis.Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and preventionStressed to death: targeting endoplasmic reticulum stress response induced apoptosis in gliomas.The deadly connection between endoplasmic reticulum, Ca2+, protein synthesis, and the endoplasmic reticulum stress response in malignant glioma cells.Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells.Misfolded proteins: from little villains to little helpers in the fight against cancer.Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series.Nelfinavir impairs glycosylation of herpes simplex virus 1 envelope proteins and blocks virus maturationA review of the mammalian unfolded protein response.Isothermal microcalorimetry accurately detects bacteria, tumorous microtissues, and parasitic worms in a label-free well-plate assay.HIV Protease Inhibitors Sensitize Human Head and Neck Squamous Carcinoma Cells to Radiation by Activating Endoplasmic Reticulum Stress.Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists' arsenal.Unfolded protein response to autophagy as a promising druggable target for anticancer therapy.Heme oxygenase-1-derived bilirubin counteracts HIV protease inhibitor-mediated endothelial cell dysfunctionIs nelfinavir exposure associated with cancer incidence in HIV-positive individuals?Targeting cancer stem cells expressing an embryonic signature with anti-proteases to decrease their tumor potential.Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion.Repositioning HIV protease inhibitors as cancer therapeuticsComparison of epigenetic profiles of human oral epithelial cells from HIV-positive (on HAART) and HIV-negative subjectsDo antiretrovirals reduce the risk of non-AIDS-defining malignancies?Identification of endoplasmic reticulum stress-inducing agents by antagonizing autophagy: a new potential strategy for identification of anti-cancer therapeutics in B-cell malignanciesThe impact of nelfinavir exposure on cancer development among a large cohort of HIV-infected patientsEndoplasmic reticulum stress: its role in disease and novel prospects for therapy.Phase I study of nelfinavir in liposarcoma.Targeting endoplasmic reticulum signaling pathways in cancer.The unfolded protein response triggered by environmental factors.Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma.Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).Pharmacological eEF2K activation promotes cell death and inhibits cancer progression.Targeting the AKT pathway: Repositioning HIV protease inhibitors as radiosensitizers.Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells.HIV-protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO-hybridized derivatives?Antitumour effects of a protease inhibitor, nelfinavir, in hepatocellular carcinoma cancer cells.The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo
P2860
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P2860
HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress.
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
HIV-1 protease inhibitors nelf ...... endoplasmic reticulum stress.
@ast
HIV-1 protease inhibitors nelf ...... endoplasmic reticulum stress.
@en
HIV-1 protease inhibitors nelf ...... endoplasmic reticulum stress.
@nl
type
label
HIV-1 protease inhibitors nelf ...... endoplasmic reticulum stress.
@ast
HIV-1 protease inhibitors nelf ...... endoplasmic reticulum stress.
@en
HIV-1 protease inhibitors nelf ...... endoplasmic reticulum stress.
@nl
prefLabel
HIV-1 protease inhibitors nelf ...... endoplasmic reticulum stress.
@ast
HIV-1 protease inhibitors nelf ...... endoplasmic reticulum stress.
@en
HIV-1 protease inhibitors nelf ...... endoplasmic reticulum stress.
@nl
P2093
P1433
P1476
HIV-1 protease inhibitors nelf ...... g endoplasmic reticulum stress
@en
P2093
Adel Kardosh
Axel H Schönthal
Peter Pyrko
Thomas C Chen
Weijun Wang
P304
10920-10928
P356
10.1158/0008-5472.CAN-07-0796
P407
P577
2007-11-01T00:00:00Z