Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. - Wikidata - wikimedia - TriplyDB

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

http://www.wikidata.org/entity/Q34718424

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Structure-guided design of selective Epac1 and Epac2 agonists Role of EPAC in cAMP-Mediated Actions in Adrenocortical Cells β-Cell glutamate signaling: Its role in incretin-induced insulin secretion Pancreatic regulation of glucose homeostasis Human β-cell proliferation and intracellular signaling: part 3 Distinct initial SNARE configurations underlying the diversity of exocytosis Cyclic AMP dynamics in the pancreatic β-cell Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells Granuphilin exclusively mediates functional granule docking to the plasma membrane.Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes Neurexins and neuroligins: synapses look out of the nervous system The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells A Novel Diphenylthiosemicarbazide Is a Potential Insulin Secretagogue for Anti-Diabetic Agen Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels Distinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin.The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.Munc18b is a major mediator of insulin exocytosis in rat pancreatic β-cells Establishment of new clonal pancreatic β-cell lines (MIN6-K) useful for study of incretin/cyclic adenosine monophosphate signaling Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature.Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles.Efficacy and safety of sitagliptin monotherapy and combination therapy in Japanese type 2 diabetes patients GIP and GLP-1, the two incretin hormones: Similarities and differences Glucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytes YES, a Src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cells Sphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion MicroRNA-7a regulates pancreatic β cell function.PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.Small G proteins in islet beta-cell function.Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis.cAMP mediators of pulsatile insulin secretion from glucose-stimulated single beta-cells.Essential role of the small GTPase Ran in postnatal pancreatic islet development.Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.Treating diabetes today: a matter of selectivity of sulphonylureas.

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

http://www.wikidata.org/entity/Q34718424

description

2007 nî lūn-bûn

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2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

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type

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

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Proceedings of the National Academy of Sciences of the United States of America

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP

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Atsuko Tamamoto

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Changliang Zhang

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Harumi Takahashi

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Kimio Matsumura

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Mami Yamanaka

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Susumu Seino

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Yasuhiro Sunaga

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P2860

A family of cAMP-binding proteins that directly activate Rap1

RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

The synaptic vesicle cycle

A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells

Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

Evidence for the involvement of cAMP-GEF (Epac) pathway in amylase release from the rat parotid gland

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104

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Jun-ichi Miyazaki

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5807881

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