Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde.
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MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repairMolecular pathogenesis and clinical management of Fanconi anemiaHow the fanconi anemia pathway guards the genomeAcetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesisApplication of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: from yeast to humanFanconi anemia and the cell cycle: new perspectives on aneuploidyBLM protein mitigates formaldehyde-induced genomic instabilityMouse models of Fanconi anemiaFanconi anaemia and the repair of Watson and Crick DNA crosslinksFormaldehyde and leukemia: epidemiology, potential mechanisms, and implications for risk assessmentFunctional Toxicogenomic Profiling Expands Insight into Modulators of Formaldehyde Toxicity in YeastThe role of the Fanconi anemia network in the response to DNA replication stress.Cellular pathways for DNA repair and damage tolerance of formaldehyde-induced DNA-protein crosslinksA novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants.Functional toxicology: tools to advance the future of toxicity testing.20S immunoproteasomes remove formaldehyde-damaged cytoplasmic proteins suppressing caspase-independent cell death.Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVATumor suppressor RecQL5 controls recombination induced by DNA crosslinking agentsHematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.Metabolism: alcohol, DNA and disease.Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.Detection of PIGO-deficient cells using proaerolysin: a valuable tool to investigate mechanisms of mutagenesis in the DT40 cell systemFormaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.Accumulation of true single strand breaks and AP sites in base excision repair deficient cellsTargeting aldehyde dehydrogenase 2: new therapeutic opportunities.Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.Functional toxicogenomics: mechanism-centered toxicology.The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines.SWI/SNF complexes are required for full activation of the DNA-damage response.Rescue of replication failure by Fanconi anaemia proteins.Proteasome activity is important for replication recovery, CHK1 phosphorylation and prevention of G2 arrest after low-dose formaldehyde.Formaldehyde-induced genome instability is suppressed by an XPF-dependent pathway.Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells.Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent ChromiumDetection of DNA-protein crosslinks (DPCs) by novel direct fluorescence labeling methods: distinct stabilities of aldehyde and radiation-induced DPCs.Fancb deficiency impairs hematopoietic stem cell function.Adverse effect of mild temperature hyperthermia combined with hexamethylenetetramine compared to its effect combined with tirapazamine in the treatment of solid tumors.ATM and KAT5 safeguard replicating chromatin against formaldehyde damage.
P2860
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P2860
Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde.
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Cells deficient in the FANC/BR ...... plasma levels of formaldehyde.
@ast
Cells deficient in the FANC/BR ...... plasma levels of formaldehyde.
@en
Cells deficient in the FANC/BR ...... plasma levels of formaldehyde.
@nl
type
label
Cells deficient in the FANC/BR ...... plasma levels of formaldehyde.
@ast
Cells deficient in the FANC/BR ...... plasma levels of formaldehyde.
@en
Cells deficient in the FANC/BR ...... plasma levels of formaldehyde.
@nl
prefLabel
Cells deficient in the FANC/BR ...... plasma levels of formaldehyde.
@ast
Cells deficient in the FANC/BR ...... plasma levels of formaldehyde.
@en
Cells deficient in the FANC/BR ...... plasma levels of formaldehyde.
@nl
P2093
P1433
P1476
Cells deficient in the FANC/BR ...... plasma levels of formaldehyde.
@en
P2093
April M Luke
Ayumi Nakamura
David A F Gillespie
Douglas K Bishop
Eiichiro Sonoda
Hiroshi Arakawa
James A Swenberg
Jean-Marie Buerstedde
John R Ridpath
Julian E Sale
P304
11117-11122
P356
10.1158/0008-5472.CAN-07-3028
P407
P577
2007-12-01T00:00:00Z