Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis - Wikidata - wikimedia - TriplyDB

Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

http://www.wikidata.org/entity/Q34729456

about

Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells Apoptosis, Necrosis, and Necroptosis in the Gut and Intestinal Homeostasis Genetically engineered mouse models for studying inflammatory bowel disease Diet, microbiome, and the intestinal epithelium: an essential triumvirate?Innate immune signaling in defense against intestinal microbes Ontogeny of intestinal epithelial innate immune responses Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis Activation of TGF-β activated kinase 1 promotes colon mucosal pathogenesis in inflammatory bowel disease.Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis.Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis NOD-like receptors in intestinal homeostasis and epithelial tissue repair.The prevalence of TNFα-induced necrosis over apoptosis is determined by TAK1-RIP1 interplay.Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis.PI3K-dependent GSK3ß(Ser9)-phosphorylation is implicated in the intestinal epithelial cell wound-healing response.Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia Epithelial barrier: an interface for the cross-communication between gut flora and immune system.TAK1 control of cell death.Intestinal inflammation and mucosal barrier function.Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology Neonatal immune adaptation of the gut and its role during infections.Gut microbiome and anticancer immune response: really hot Sh*t!Intestinal-specific TNFα overexpression induces Crohn's-like ileitis in mice Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease.Transforming growth factor β-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling Activated macrophage survival is coordinated by TAK1 binding proteins The pathogenesis, detection, and prevention of Vibrio parahaemolyticus.Maturation of the enteric mucosal innate immune system during the postnatal period.NF-κB in the regulation of epithelial homeostasis and inflammation.c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-α signaling and ROS production.TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB, and Bnip3 Pathways.TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration.TAK1 regulates Paneth cell integrity partly through blocking necroptosis.A Vibrio parahaemolyticus T3SS effector mediates pathogenesis by independently enabling intestinal colonization and inhibiting TAK1 activation.

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P2860

Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

http://www.wikidata.org/entity/Q34729456

description

2008 nî lūn-bûn

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2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հուլիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Enterocyte-derived TAK1 signal ...... lopment of ileitis and colitis

@ast

Enterocyte-derived TAK1 signal ...... lopment of ileitis and colitis

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Enterocyte-derived TAK1 signal ...... lopment of ileitis and colitis

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type

label

Enterocyte-derived TAK1 signal ...... lopment of ileitis and colitis

@ast

Enterocyte-derived TAK1 signal ...... lopment of ileitis and colitis

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Enterocyte-derived TAK1 signal ...... lopment of ileitis and colitis

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prefLabel

Enterocyte-derived TAK1 signal ...... lopment of ileitis and colitis

@ast

Enterocyte-derived TAK1 signal ...... lopment of ileitis and colitis

@en

Enterocyte-derived TAK1 signal ...... lopment of ileitis and colitis

@nl

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JIMMUNOL.181.2.1143

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Journal of Immunology

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Enterocyte-derived TAK1 signal ...... lopment of ileitis and colitis

@en

P2093

Christian Jobin

http://www.w3.org/2001/XMLSchema#string

Elisabeth Lippert

http://www.w3.org/2001/XMLSchema#string

Kunihiro Matsumoto

http://www.w3.org/2001/XMLSchema#string

Maiko Inagaki

http://www.w3.org/2001/XMLSchema#string

Shizuo Akira

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Sylvie Robine

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P2860

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice

The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling.

The gut flora as a forgotten organ

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

Pathogen recognition and innate immunity

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.

The TGF beta activated kinase TAK1 regulates vascular development in vivo

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

Unravelling the pathogenesis of inflammatory bowel disease

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1143-1152

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scholarly article

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10.4049/JIMMUNOL.181.2.1143

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2

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181

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Jun Ninomiya-Tsuji

Rie Kajino-Sakamoto

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2008-07-01T00:00:00Z

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5245662

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18606667

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3065656

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