Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. - Wikidata - wikimedia - TriplyDB

Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function.

Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function.

http://www.wikidata.org/entity/Q34732687

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Rap1 GTPases: an emerging role in the cardiovasculature Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics The leading role of microtubules in endothelial barrier dysfunction: disassembly of peripheral microtubules leaves behind the cytoskeletal reorganization.AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP.Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses The future of EPAC-targeted therapies: agonism versus antagonism Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing.Rap1 and Rap2 antagonistically control endothelial barrier resistance.Epac and PKA: a tale of two intracellular cAMP receptors.DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.Prevention of estradiol 17beta-D-glucuronide-induced canalicular transporter internalization by hormonal modulation of cAMP in rat hepatocytes.EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.PDE4 regulates tissue plasminogen activator expression of human brain microvascular endothelial cells Heat-labile enterotoxin-induced activation of NF-κB and MAPK pathways in intestinal epithelial cells impacts enterotoxigenic Escherichia coli (ETEC) adherence.AKAP9, a Regulator of Microtubule Dynamics, Contributes to Blood-Testis Barrier Function.Role of Exchange Protein Activated by cAMP 1 in Regulating Rates of Microtubule Formation in Cystic Fibrosis Epithelial Cells.The role of cytoskeleton in the regulation of vascular endothelial barrier function.Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29.Endothelial signaling in paracellular and transcellular leukocyte transmigration Molecular mechanisms mediating protective effect of cAMP on lipopolysaccharide (LPS)-induced human lung microvascular endothelial cells (HLMVEC) hyperpermeability.Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.EPAC proteins transduce diverse cellular actions of cAMP.Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature.Emerging themes of cAMP regulation of the pulmonary endothelial barrier.Regulation of the inflammatory response of vascular endothelial cells by EPAC1.Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).Interactions between Epac1 and ezrin in the control of endothelial barrier function.The small GTPase Rap1 is a novel regulator of RPE cell barrier function.The role of small GTPases and EPAC-Rap signaling in the regulation of the blood-brain and blood-retinal barriers.Intracellular ascorbate tightens the endothelial permeability barrier through Epac1 and the tubulin cytoskeleton.Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis.Functions for the cAMP/Epac/Rap1 Signaling Pathway in Low-Dose Endothelial Monocyte-Activating Polypeptide-II-Induced Opening of Blood-Tumor Barrier.The microRNA-7-mediated reduction in EPAC-1 contributes to vascular endothelial permeability and eNOS uncoupling in murine experimental retinopathy.Role of cAMP-dependent protein kinase A activity in low-dose endothelial monocyte-activating polypeptide-II-induced opening of blood-tumor barrier.VE-cadherin signaling induces EB3 phosphorylation to suppress microtubule growth and assemble adherens junctions.Rap1 signaling in endothelial barrier control.

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P2860

Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function.

http://www.wikidata.org/entity/Q34732687

description

2008 nî lūn-bûn

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2008 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հունվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Role of Epac1, an exchange fac ...... dynamics and barrier function.

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Role of Epac1, an exchange fac ...... dynamics and barrier function.

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Role of Epac1, an exchange fac ...... dynamics and barrier function.

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Role of Epac1, an exchange fac ...... dynamics and barrier function.

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Role of Epac1, an exchange fac ...... dynamics and barrier function.

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Role of Epac1, an exchange fac ...... dynamics and barrier function.

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MBC.E06-10-0972

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Molecular Biology of the Cell

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Role of Epac1, an exchange fac ...... dynamics and barrier function.

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Joseph Italiano

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Seema Sehrawat

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Sunita Patel

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Tanya N Mayadas

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Xavier Cullere

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P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth

Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes

The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin

Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties

Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

Feedback interactions between cell-cell adherens junctions and cytoskeletal dynamics in newt lung epithelial cells.

Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes.

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1261-1270

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scholarly article

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10.1091/MBC.E06-10-0972

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3

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19

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18172027

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2262967

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