CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. - Wikidata - wikimedia - TriplyDB

CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice.

CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice.

http://www.wikidata.org/entity/Q36173604

about

The chemopreventive effects of Protandim: modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis Targeting Oncogenic Mutant p53 for Cancer Therapy Tumor suppressor p53 and its gain-of-function mutants in cancer Targeted rescue of a destabilized mutant of p53 by an in silico screened drug Targeting p53 for Novel Anticancer Therapy.Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells.Determination and stability of CP-31398 in plasma from experimental animals by LC-MS/MS.Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis.A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers.Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma.Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells.Pathogenesis of nonmelanoma skin cancers in organ transplant recipients Procarcinogenic effects of cyclosporine A are mediated through the activation of TAK1/TAB1 signaling pathway Curcuminoids activate p38 MAP kinases and promote UVB-dependent signalling in keratinocytes Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: role of TGFβ signaling pathway.Functional repair of p53 mutation in colorectal cancer cells using trans-splicing.Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma.Translational approaches targeting the p53 pathway for anti-cancer therapy.Genotoxicity of the cancer chemopreventive drug candidates CP-31398, SHetA2, and phospho-ibuprofen.Targeting mutant p53 shows promise for sunscreens and skin cancer Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells.TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma.Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs Molecular basis for the tissue specificity of β-catenin oncogenesis.Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo.Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ mice Fisetin inhibits growth, induces G₂ /M arrest and apoptosis of human epidermoid carcinoma A431 cells: role of mitochondrial membrane potential disruption and consequent caspases activation.p53-stabilizing agent CP-31398 prevents growth and invasion of urothelial cancer of the bladder in transgenic UPII-SV40T mice.The antiproliferative function of violacein-like purple violet pigment (PVP) from an Antarctic Janthinobacterium sp. Ant5-2 in UV-induced 2237 fibrosarcoma.Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice.Pharmacological activation of p53 in cancer cells Nitric oxide-releasing sulindac is a novel skin cancer chemopreventive agent for UVB-induced photocarcinogenesis.Targeting the p53 pathway.Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells Cytoplasmic functions of the tumour suppressor p53.Inhibition of azoxymethane-induced colorectal cancer by CP-31398, a TP53 modulator, alone or in combination with low doses of celecoxib in male F344 rats.Targeting cancer stem cells with p53 modulators.Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in Ptch(+/-) mice.Resuscitating wild-type p53 expression by disrupting ceramide glycosylation: a novel approach to target mutant p53 tumors.

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P2860

CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice.

http://www.wikidata.org/entity/Q36173604

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

@zh-tw

2007年论文

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2007年论文

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2007年论文

@zh-cn

name

CP-31398 restores mutant p53 t ...... d skin carcinogenesis in mice.

@ast

CP-31398 restores mutant p53 t ...... d skin carcinogenesis in mice.

@en

type

label

CP-31398 restores mutant p53 t ...... d skin carcinogenesis in mice.

@ast

CP-31398 restores mutant p53 t ...... d skin carcinogenesis in mice.

@en

prefLabel

CP-31398 restores mutant p53 t ...... d skin carcinogenesis in mice.

@ast

CP-31398 restores mutant p53 t ...... d skin carcinogenesis in mice.

@en

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P1433

Journal of Clinical Investigation

P1476

CP-31398 restores mutant p53 t ...... d skin carcinogenesis in mice.

@en

P2093

Arianna L Kim

http://www.w3.org/2001/XMLSchema#string

David R Bickers

http://www.w3.org/2001/XMLSchema#string

Levy Kopelovich

http://www.w3.org/2001/XMLSchema#string

Lydia Han

http://www.w3.org/2001/XMLSchema#string

Mohammad Athar

http://www.w3.org/2001/XMLSchema#string

Xiuwei Tang

http://www.w3.org/2001/XMLSchema#string

Yucui Zhu

http://www.w3.org/2001/XMLSchema#string

P2860

p53 has a direct apoptogenic role at the mitochondria

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Surfing the p53 network

Cancer genes and the pathways they control

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

UV damage, DNA repair and skin carcinogenesis

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Restoration of p53 function leads to tumour regression in vivo

Mutations in cancer genes of UV-induced skin tumors of hairless mice.

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

P304

3753-3764

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scholarly article

P356

10.1172/JCI32481

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12

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117

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2007-12-01T00:00:00Z

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18060030

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2096455

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