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Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

http://www.wikidata.org/entity/Q34758220

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Viral markers for HIV cure trials: are we getting any closer?How to Define the Latent Reservoir: Tools of the Trade Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1 Hematopoietic Stem and Immune Cells in Chronic HIV Infection CCR5 Targeted Cell Therapy for HIV and Prevention of Viral Escape Dynamic models of viral replication and latency Using animal models to overcome temporal, spatial and combinatorial challenges in HIV persistence research Advances in biosensing strategies for HIV-1 detection, diagnosis, and therapeutic monitoring.The use of Nanotrap particles technology in capturing HIV-1 virions and viral proteins from infected cells.Measuring reversal of HIV-1 latency ex vivo using cells from infected individuals Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy.High-throughput Characterization of HIV-1 Reservoir Reactivation Using a Single-Cell-in-Droplet PCR Assay.Immunity to HIV in Early Life Dendritic cells restore CD8+ T cell reactivity to autologous HIV-1 HIV-1 DNA predicts disease progression and post-treatment virological control.HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption.Progress toward curing HIV infections with hematopoietic stem cell transplantation.HIV-1 integration landscape during latent and active infection Real-time label-free measurement of HIV-1 protease activity by nanopore analysis.Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques.Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo Hydrogen Peroxide Induce Human Cytomegalovirus Replication through the Activation of p38-MAPK Signaling Pathway.Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals Ex Vivo Bioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4(+) T Cells from Aviremic Patients.A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNA Measuring the latent reservoir in vivo.In vivo platforms for analysis of HIV persistence and eradication.The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb.Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells Animal models to achieve an HIV cure Defective proviruses rapidly accumulate during acute HIV-1 infection Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells.Chimeric Antigen Receptor T Cells Guided by the Single-Chain Fv of a Broadly Neutralizing Antibody Specifically and Effectively Eradicate Virus Reactivated from Latency in CD4+ T Lymphocytes Isolated from HIV-1-Infected Individuals Receiving Suppres International AIDS Society global scientific strategy: towards an HIV cure 2016.A highly reproducible quantitative viral outgrowth assay for the measurement of the replication-competent latent HIV-1 reservoir New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.

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Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

http://www.wikidata.org/entity/Q34758220

description

2013 nî lūn-bûn

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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2013 թվականի մայիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

@zh-hans

2013年学术文章

@zh-my

2013年学术文章

@zh-sg

2013年學術文章

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name

Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

@ast

Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

@en

Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

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type

label

Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

@ast

Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

@en

Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

@nl

prefLabel

Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

@ast

Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

@en

Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

@nl

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JOURNAL.PPAT.1003398

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Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay

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Evelyn E Eisele

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Gregory M Laird

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Janet D Siliciano

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Joel N Blankson

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Jun Lai

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S Alireza Rabi

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Stanley Chioma

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P2860

Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid

Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

Recovery of replication-competent HIV despite prolonged suppression of plasma viremia

Decay characteristics of HIV-1-infected compartments during combination therapy

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation

Biphasic decay of latently infected CD4+ T cells in acute human immunodeficiency virus type 1 infection.

Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.

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e1003398

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10.1371/JOURNAL.PPAT.1003398

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5

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Robert F. Siliciano

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2013-05-30T00:00:00Z

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