Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.
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Crystal Structure of an Activated Variant of Small Heat Shock Protein Hsp16.5Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury.HSPA1A-independent suppression of PARK2 C289G protein aggregation by human small heat shock proteinsDysregulation of RNA Binding Protein Aggregation in Neurodegenerative Disorders.Human-derived physiological heat shock protein 27 complex protects brain after focal cerebral ischemia in mice.Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathyMolecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.Sequence, structure, and dynamic determinants of Hsp27 (HspB1) equilibrium dissociation are encoded by the N-terminal domain.Heat shock response and insulin-associated neurodegeneration.DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.The neuroregenerative mechanism mediated by the Hsp90-binding immunophilin FKBP52 resembles the early steps of neuronal differentiation.Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target.Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.Imbalance of Hsp70 family variants fosters tau accumulation.Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain.Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradationAccelerated neurodegeneration through chaperone-mediated oligomerization of tau.ER-stress in Alzheimer's disease: turning the scale?Neuronal life span versus health span: principles of natural selection at work in the degenerating brain.Potential synergy between tau aggregation inhibitors and tau chaperone modulators.Barcoding heat shock proteins to human diseases: looking beyond the heat shock responseCellular factors modulating the mechanism of tau protein aggregation.Molecular chaperones and neuronal proteostasis.Therapeutic Strategies for Restoring Tau Homeostasis.Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1.Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics.Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.Reconstructing the Hsp90/Tau Machine.HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation.Human Umbilical Cord Mesenchymal Stem Cells Protect Against SCA3 by Modulating the Level of 70 kD Heat Shock Protein.A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventricular injection of lipopolysaccharide in rats.Expansion of corticomedullary junction high-susceptibility region (CMJ-HSR) with aging: a clue in the pathogenesis of Alzheimer's disease?Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach.Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator.Mapping interactions with the chaperone network reveals factors that protect against tau aggregationCompeting protein-protein interactions regulate binding of Hsp27 to its client protein tau
P2860
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P2860
Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Phosphorylation dynamics regul ...... ficits in tau transgenic mice.
@ast
Phosphorylation dynamics regul ...... ficits in tau transgenic mice.
@en
Phosphorylation dynamics regul ...... ficits in tau transgenic mice.
@nl
type
label
Phosphorylation dynamics regul ...... ficits in tau transgenic mice.
@ast
Phosphorylation dynamics regul ...... ficits in tau transgenic mice.
@en
Phosphorylation dynamics regul ...... ficits in tau transgenic mice.
@nl
prefLabel
Phosphorylation dynamics regul ...... ficits in tau transgenic mice.
@ast
Phosphorylation dynamics regul ...... ficits in tau transgenic mice.
@en
Phosphorylation dynamics regul ...... ficits in tau transgenic mice.
@nl
P2093
P2860
P50
P1476
Phosphorylation dynamics regul ...... eficits in tau transgenic mice
@en
P2093
Amelia G Johnson
Chad A Dickey
Clara Kraft
Donna Wilcock
Edwin J Weeber
Jessica Banko
John C O'Leary
Jose F Abisambra
Justin Rogers
Karen Jansen-West
P2860
P304
15374-15382
P356
10.1523/JNEUROSCI.3155-10.2010
P407
P577
2010-11-01T00:00:00Z