Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.
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Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function StudiesLacritin and other autophagy associated proteins in ocular surface health.The glaucoma-associated olfactomedin domain of myocilin forms polymorphic fibrils that are constrained by partial unfolding and peptide sequenceInvolvement of the Akt signaling pathway in ER-α36/GRP94-mediated signaling in gastric cancer.Ligands for glaucoma-associated myocilin discovered by a generic binding assayStructural basis for misfolding in myocilin-associated glaucoma.Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma.Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation.Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide ScaffoldA Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture.The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review.The cell stress machinery and retinal degeneration.Targeting Hsp90 and its co-chaperones to treat Alzheimer's diseaseNatural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?Targeting the ER-autophagy system in the trabecular meshwork to treat glaucomaDiscovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.Development of radamide analogs as Grp94 inhibitorsExploiting the interaction between Grp94 and aggregated myocilin to treat glaucomaIsoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma.Resorcinol-Based Grp94-Selective Inhibitors.Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold.Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models.Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
P2860
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P2860
Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
Glucose-regulated protein 94 t ...... utophagic clearance mechanism.
@ast
Glucose-regulated protein 94 t ...... utophagic clearance mechanism.
@en
type
label
Glucose-regulated protein 94 t ...... utophagic clearance mechanism.
@ast
Glucose-regulated protein 94 t ...... utophagic clearance mechanism.
@en
prefLabel
Glucose-regulated protein 94 t ...... utophagic clearance mechanism.
@ast
Glucose-regulated protein 94 t ...... utophagic clearance mechanism.
@en
P2093
P2860
P921
P356
P1476
Glucose-regulated protein 94 t ...... utophagic clearance mechanism.
@en
P2093
Adam S Duerfeldt
Amirthaa Suntharalingam
Brian S J Blagg
Chad A Dickey
John C O'Leary
Jose F Abisambra
Laura J Blair
Matthew Cockman
Myung Kuk Joe
P2860
P304
40661-40669
P356
10.1074/JBC.M112.384800
P407
P50
P577
2012-10-03T00:00:00Z