p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. - Wikidata - wikimedia - TriplyDB

p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop.

p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop.

http://www.wikidata.org/entity/Q34794097

about

Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion The transcription factor p53: not a repressor, solely an activator Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1 Myosin VI is a mediator of the p53-dependent cell survival pathway.Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma Discoidin Domain Receptors: Potential Actors and Targets in Cancer A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness Discoidin domain receptor functions in physiological and pathological conditions.ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1.Ras puts the brake on doxorubicin-mediated cell death in p53-expressing cells A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration.Genotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53.Mechanisms that enhance sustainability of p53 pulses Identification of receptor tyrosine kinase, discoidin domain receptor 1 (DDR1), as a potential biomarker for serous ovarian cancer.DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation.Signaling from p53 to NF-kappa B determines the chemotherapy responsiveness of neuroblastoma.Matrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition.Discoidin domain receptor tyrosine kinases: new players in cancer progression CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1.Modulation of response to tumor therapies by the extracellular matrix.Targeting prostate cancer based on signal transduction and cell cycle pathways.The dark side of a tumor suppressor: anti-apoptotic p53.Rational drug redesign to overcome drug resistance in cancer therapy: imatinib moving target.Antitumor activity of 7RH, a discoidin domain receptor 1 inhibitor, alone or in combination with dasatinib exhibits antitumor effects in nasopharyngeal carcinoma cells.Mapping of DDR1 distribution and oligomerization on the cell surface by FRET microscopy.Small-molecule inhibitors binding to protein kinase. Part II: the novel pharmacophore approach of type II and type III inhibition.Differential recognition of response elements determines target gene specificity for p53 and p63 The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation.Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma.DDR1 enhances invasion and metastasis of gastric cancer via epithelial-mesenchymal transition.The Paradox of p53: What, How, and Why?Discoidin domain receptor 1 is associated with poor prognosis of non-small cell lung cancer and promotes cell invasion via epithelial-to-mesenchymal transition.Migration inhibition of mammary epithelial cells by Syk is blocked in the presence of DDR1 receptors.Collagen I regulates the self-renewal of mouse embryonic stem cells through α2β1 integrin- and DDR1-dependent Bmi-1.

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P2860

p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop.

http://www.wikidata.org/entity/Q34794097

description

2003 nî lūn-bûn

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2003 թուականի Մարտին հրատարակուած գիտական յօդուած

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2003 թվականի մարտին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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p53 induction and activation o ...... ough a positive feedback loop.

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p53 induction and activation o ...... ough a positive feedback loop.

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p53 induction and activation o ...... ough a positive feedback loop.

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p53 induction and activation o ...... ough a positive feedback loop.

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p53 induction and activation o ...... ough a positive feedback loop.

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The EMBO Journal

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p53 induction and activation o ...... ough a positive feedback loop.

@en

P2093

George D Yancopoulos

http://www.w3.org/2001/XMLSchema#string

Jong-il Kim

http://www.w3.org/2001/XMLSchema#string

Li Fang

http://www.w3.org/2001/XMLSchema#string

Pat P Ongusaha

http://www.w3.org/2001/XMLSchema#string

Sam W Lee

http://www.w3.org/2001/XMLSchema#string

Stuart A Aaronson

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Tai W Wong

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P2860

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

The discoidin domain receptor tyrosine kinases are activated by collagen

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain

A simplified system for generating recombinant adenoviruses

Cell signaling by receptor tyrosine kinases

p53, the cellular gatekeeper for growth and division

WAF1, a potential mediator of p53 tumor suppression

Surfing the p53 network

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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1289-1301

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scholarly article

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10.1093/EMBOJ/CDG129

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6

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22

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2003-03-01T00:00:00Z

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10863199

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12628922

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151063

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