A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer.
about
Therapeutic Rationales, Progresses, Failures, and Future Directions for Advanced Prostate CancerProgress of molecular targeted therapies for prostate cancersAdvances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancersTargeting the adaptive molecular landscape of castration-resistant prostate cancerHeat shock and other apoptosis-related proteins as therapeutic targets in prostate cancerIdentification, design and bio-evaluation of novel Hsp90 inhibitors by ligand-based virtual screeningIdentification of the plant compound geraniin as a novel Hsp90 inhibitorInhibition of Hsp90 augments docetaxel therapy in castrate resistant prostate cancerHsp90 blockers inhibit adipocyte differentiation and fat mass accumulationThe HSP90 inhibitor NVP-AUY922 radiosensitizes by abrogation of homologous recombination resulting in mitotic entry with unresolved DNA damageMarked enhancement of lysosomal targeting and efficacy of ErbB2-targeted drug delivery by HSP90 inhibitionAddressing taxane resistance in metastatic castration-resistant prostate cancer: a focus on chaperone proteins.Acetylation of androgen receptor by ARD1 promotes dissociation from HSP90 complex and prostate tumorigenesis.Synergistic administration of photothermal therapy and chemotherapy to cancer cells using polypeptide-based degradable plasmonic matrices.Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumorsTargeting the 90 kDa heat shock protein improves photodynamic therapy.Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluationHsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics.Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directionsTargeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease.Macrocyclic inhibitors of hsp90Castration-resistant prostate cancer: new science and therapeutic prospects.Multicenter phase II trial of the heat shock protein 90 inhibitor, retaspimycin hydrochloride (IPI-504), in patients with castration-resistant prostate cancerTopically applied Hsp90 inhibitor 17AAG inhibits UVR-induced cutaneous squamous cell carcinomasHsp90 inhibitor can inhibit UV carcinogenesis.The human immunodeficiency virus protease inhibitor ritonavir is potentially active against urological malignancies.BCAS2 promotes prostate cancer cells proliferation by enhancing AR mRNA transcription and protein stability.17-ABAG, a novel geldanamycin derivative, inhibits LNCaP-cell proliferation through heat shock protein 90 inhibition.The HSP90 inhibitor 17-PAG effectively inhibits the proliferation and migration of androgen-independent prostate cancer cellsNovel interaction between the co-chaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen receptor activity and prostate cancer growth.Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression.Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival.HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer.Tanespimycin: the opportunities and challenges of targeting heat shock protein 90.Novel targets in esophageal and gastric cancer: beyond antiangiogenesis.Phase I study of tanespimycin in combination with bortezomib in patients with advanced solid malignancies.Glucocorticoid Receptor-Targeted Liposomal Codelivery of Lipophilic Drug and Anti-Hsp90 Gene: Strategy to Induce Drug-Sensitivity, EMT-Reversal, and Reduced Malignancy in Aggressive Tumors.Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer.Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls.
P2860
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P2860
A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer.
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
A phase II trial of 17-allylam ...... ry metastatic prostate cancer.
@ast
A phase II trial of 17-allylam ...... ry metastatic prostate cancer.
@en
A phase II trial of 17-allylam ...... ry metastatic prostate cancer.
@nl
type
label
A phase II trial of 17-allylam ...... ry metastatic prostate cancer.
@ast
A phase II trial of 17-allylam ...... ry metastatic prostate cancer.
@en
A phase II trial of 17-allylam ...... ry metastatic prostate cancer.
@nl
prefLabel
A phase II trial of 17-allylam ...... ry metastatic prostate cancer.
@ast
A phase II trial of 17-allylam ...... ry metastatic prostate cancer.
@en
A phase II trial of 17-allylam ...... ry metastatic prostate cancer.
@nl
P2093
P2860
P1476
A phase II trial of 17-allylam ...... ry metastatic prostate cancer.
@en
P2093
Charles Erlichman
David W Hillman
Elisabeth I Heath
Fazlul Sarkar
Felicity Harper
Henry C Pitot
Melvin Gaskins
Michael A Carducci
Roberto Pili
P2860
P304
P356
10.1158/1078-0432.CCR-08-0221
P407
P577
2008-12-01T00:00:00Z