Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.
about
Macrocyclic histone deacetylase inhibitorsTiny Microbes with a Big Impact: The Role of Cyanobacteria and Their Metabolites in Shaping Our FutureLargazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1)Chemical phylogenetics of histone deacetylases.Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry.Potent and orally efficacious bisthiazole-based histone deacetylase inhibitorsEnzymatic activation of a matrix metalloproteinase inhibitorSynthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors.A novel HDAC inhibitor with a hydroxy-pyrimidine scaffoldEvaluation of class I HDAC isoform selectivity of largazole analoguesModulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug PropertiesSynthesis and biological evaluation of largazole analogues with modified surface recognition cap groupsTotal synthesis of Lys(3) tamandarin M: a potential affinity ligand.In Vitro and In Vivo Osteogenic Activity of Largazole.Macrolactonization of peptide thioesters catalyzed by imidazole and its application in the synthesis of kahalalide B and analoguesBiological targets and mechanisms of action of natural products from marine cyanobacteria.Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostereNatural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.Variable active site loop conformations accommodate the binding of macrocyclic largazole analogues to HDAC8Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes.Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.Largazole: from discovery to broad-spectrum therapy.Largazole, a class I histone deacetylase inhibitor, enhances TNF-α-induced ICAM-1 and VCAM-1 expression in rheumatoid arthritis synovial fibroblasts.Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffoldChasing the treasures of the sea - bacterial marine natural products.Discovery and mechanism of natural products as modulators of histone acetylation.Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures.Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.Epigenetics in human melanoma.Largazole pharmacokinetics in rats by LC-MS/MS.Probing the biology of natural products: molecular editing by diverted total synthesis.Thiazole and oxazole alkaloids: isolation and synthesis.A review of pharmacological and toxicological potentials of marine cyanobacterial metabolites.Synthesis and biological evaluation of largazole zinc-binding group analogs.Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes.A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling.Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis.
P2860
Q24629065-59705EF3-6823-4C7D-B322-4AB1462D2B78Q26747668-6ACDEB94-4C53-40F4-82BD-16C746210B94Q28258201-1F894E29-E739-4C5B-A5F4-744F6C4CF824Q30977637-7453AF92-A38F-4240-A942-F0C13E57EB0FQ33496543-860310D5-86A6-4514-AE63-A718E008EBEAQ33636013-AE774480-4180-4570-A42C-CA45871AF853Q33768549-955997D6-955C-41A3-BD9F-F34E606C8CB9Q33839227-3884CD23-3C7A-4768-BDF1-1BFDE879A0C6Q33893992-9D53AA17-C530-4504-9418-78464DE6ABB6Q33934129-C5C3BC14-98B3-4F64-BC06-73E0BD1CBCD0Q33940304-4CA0AB0A-86C9-4985-8276-C2D6BE48C7A4Q34054267-AC5FE43E-FA56-4A4E-AEA3-F63B350C40FDQ34063722-1C9BA2AE-B8F9-4F14-9E74-C53CCFF16BEAQ34302247-C9D132B7-507F-4D58-89AD-0B1EAC50AE9BQ34680440-B57B112A-C127-4FD5-829C-67743BC7B18EQ35030533-DB418B05-C57B-4E27-A719-E8961383CD26Q35055393-2AF1BCBF-890A-4922-AC65-5B2C4C1A7D6AQ35130835-A9C8E07D-69F3-45E3-A271-449F72AE31AFQ35202369-4C7594A1-19AA-4747-ADC0-B872380D0E6CQ35215703-FD8D0066-B0B6-499B-8C10-8E63F8D97361Q35243482-9C201958-6229-48CF-8054-C9D70C095F35Q35597103-D5239863-D755-4451-8332-E065EF9F9147Q35656966-0A92682F-8B54-4866-8C2D-237E29F135D3Q36649018-59C367C8-AB99-467F-B3A1-7B1896CDBBEEQ37155203-AD709786-92ED-4A8A-8A20-AC35F9CF44D9Q37170927-86EF8669-E905-453A-939E-793DE5C2A3E5Q37226088-7B1CE533-65B4-4517-BBEC-C0A61FD5ABBCQ37242496-52287C9E-79ED-4C5B-A7E9-FB2A3CF3290CQ37362478-818D2102-33BF-4E5B-9D52-8DAC6F48B4C8Q37383739-C609A06D-796C-43FD-85E9-B2F181688DECQ37531849-17AF6004-64B6-4D1F-8CA2-45AFE0BAC135Q37667033-95462B22-57C0-4E6C-A69C-C868B4CD1403Q37809500-E5925860-D407-4855-963B-80CFD5D28D8BQ37817756-BD5C774C-E2A7-48B7-AA84-B50D8F53B123Q37930568-AC97178D-F2D2-4276-A0E0-680C6C41EACBQ38707248-9A392348-7800-43F8-BD15-B9E1A946644DQ38939048-0F73DC40-71A5-4452-BB01-31AD4C66FF21Q38982458-E473C3BB-2719-4B40-AEEB-8E77F7725A49Q39218226-BE444A87-4047-4E48-AFBA-762C8E857F41Q39606523-F233B324-13B6-4E47-A5D7-519B0C764F03
P2860
Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Total synthesis and biological ...... histone deacetylase inhibitor.
@ast
Total synthesis and biological ...... histone deacetylase inhibitor.
@en
Total synthesis and biological ...... histone deacetylase inhibitor.
@nl
type
label
Total synthesis and biological ...... histone deacetylase inhibitor.
@ast
Total synthesis and biological ...... histone deacetylase inhibitor.
@en
Total synthesis and biological ...... histone deacetylase inhibitor.
@nl
prefLabel
Total synthesis and biological ...... histone deacetylase inhibitor.
@ast
Total synthesis and biological ...... histone deacetylase inhibitor.
@en
Total synthesis and biological ...... histone deacetylase inhibitor.
@nl
P2093
P2860
P356
P1476
Total synthesis and biological ...... histone deacetylase inhibitor.
@en
P2093
Albert Bowers
Jack Taunton
James E Bradner
Nathan West
Robert M Williams
Stuart L Schreiber
P2860
P304
11219-11222
P356
10.1021/JA8033763
P407
P577
2008-07-19T00:00:00Z