The NEDD8-activating enzyme inhibitor MLN4924 disrupts nucleotide metabolism and augments the efficacy of cytarabine - Wikidata - wikimedia - TriplyDB

The NEDD8-activating enzyme inhibitor MLN4924 disrupts nucleotide metabolism and augments the efficacy of cytarabine

The NEDD8-activating enzyme inhibitor MLN4924 disrupts nucleotide metabolism and augments the efficacy of cytarabine

http://www.wikidata.org/entity/Q34979606

about

Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma.Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications.Pevonedistat, a NEDD8-activating enzyme inhibitor, is active in mantle cell lymphoma and enhances rituximab activity in vivo Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer.Comprehensive quantitative proteomic profiling of the pharmacodynamic changes induced by MLN4924 in acute myeloid leukemia cells establishes rationale for its combination with azacitidine.The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR.Protein neddylation and its alterations in human cancers for targeted therapy.

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The NEDD8-activating enzyme inhibitor MLN4924 disrupts nucleotide metabolism and augments the efficacy of cytarabine

http://www.wikidata.org/entity/Q34979606

description

2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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1078-0432.CCR-14-1960

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Clinical Cancer Research

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The NEDD8-activating enzyme in ...... nts the efficacy of cytarabine

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Hetty Carraway

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Jaroslaw P Maciejewski

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Jennifer S Carew

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Kevin R Kelly

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Mignon Keaton

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Mikkael A Sekeres

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Peter G Smith

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Steffan T Nawrocki

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Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924

A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma.

The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme.

Age and acute myeloid leukemia.

Older adults with acute myeloid leukemia.

On the value of intensive remission-induction chemotherapy in elderly patients of 65+ years with acute myeloid leukemia: a randomized phase III study of the European Organization for Research and Treatment of Cancer Leukemia Group.

Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.

A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination.

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439-447

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scholarly article

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10.1158/1078-0432.CCR-14-1960

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2

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2014-11-11T00:00:00Z

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4297545

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