Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor. - Wikidata - wikimedia - TriplyDB

Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.

Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.

http://www.wikidata.org/entity/Q35653286

about

The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair When ubiquitin meets NF-κB: a trove for anti-cancer drug development Ubiquitylation, neddylation and the DNA damage response Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924 Cellular characterization of ultrasound-stimulated microbubble radiation enhancement in a prostate cancer xenograft model.Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis.Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis Dissection of DNA damage responses using multiconditional genetic interaction maps Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis.Inhibition of Neddylation Modification Sensitizes Pancreatic Cancer Cells to Gemcitabine.Strategy to enhance the therapeutic effect of doxorubicin in human hepatocellular carcinoma by selenocystine, a synergistic agent that regulates the ROS-mediated signaling.MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinoma Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications.The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme.Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair.Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites.Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer.Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair The NEDD8-activating enzyme inhibitor MLN4924 disrupts nucleotide metabolism and augments the efficacy of cytarabine Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer.Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application Suppression of glioblastoma by targeting the overactivated protein neddylation pathway.Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells.Targeting neddylation induces DNA damage and checkpoint activation and sensitizes chronic lymphocytic leukemia B cells to alkylating agents Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells.Molecular targets and mechanisms of radiosensitization using DNA damage response pathways.Neddylation plays an important role in the regulation of murine and human dendritic cell function.Radiosensitization by the investigational NEDD8-activating enzyme inhibitor MLN4924 (pevonedistat) in hormone-resistant prostate cancer cells.Suppression of tumor angiogenesis by targeting the protein neddylation pathway.The ATP-competitive mTOR inhibitor INK128 enhances in vitro and in vivo radiosensitivity of pancreatic carcinoma cells.The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-κB activation and induces apoptosis in chronic lymphocytic leukemia B cells.New targeted approaches against the ubiquitin-proteasome system in gastrointestinal malignancies.Merlin, a multi-suppressor from cell membrane to the nucleus.MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy.Radiosensitization of Cancer Cells by Inactivation of Cullin-RING E3 Ubiquitin Ligases.Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase.Targeting neddylation in cancer therapy.

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Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.

http://www.wikidata.org/entity/Q35653286

description

2011 nî lūn-bûn

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Radiosensitization of human pa ...... 8-activating enzyme inhibitor.

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Radiosensitization of human pa ...... 8-activating enzyme inhibitor.

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type

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Radiosensitization of human pa ...... 8-activating enzyme inhibitor.

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Radiosensitization of human pa ...... 8-activating enzyme inhibitor.

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Radiosensitization of human pa ...... 8-activating enzyme inhibitor.

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Radiosensitization of human pa ...... 8-activating enzyme inhibitor.

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0008-5472.CAN-11-2866

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Cancer Research

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Radiosensitization of human pa ...... 8-activating enzyme inhibitor.

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Dongping Wei

http://www.w3.org/2001/XMLSchema#string

Hua Li

http://www.w3.org/2001/XMLSchema#string

Jie Yu

http://www.w3.org/2001/XMLSchema#string

Jonathan T Sebolt

http://www.w3.org/2001/XMLSchema#string

Lili Zhao

http://www.w3.org/2001/XMLSchema#string

Meredith A Morgan

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Peter G Smith

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Theodore S Lawrence

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Yi Sun

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P2860

Global cancer statistics

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase

Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ

DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.

RING domain E3 ubiquitin ligases

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282-293

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10.1158/0008-5472.CAN-11-2866

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1

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3251739

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