High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotrophic for methionine.
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Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)Histone methyltransferases, diet nutrients and tumour suppressors.Can dietary methionine restriction increase the effectiveness of chemotherapy in treatment of advanced cancer?Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 ExpressionSelective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity.Genetic heterogeneity among patients with methylcobalamin deficiency. Definition of two complementation groups, cblE and cblG.Genetic complementation among inherited deficiencies of methylmalonyl-CoA mutase activity: evidence for a new class of human cobalamin mutant.Reduced availability of endogenously synthesized methionine for S-adenosylmethionine formation in methionine-dependent cancer cells.De novo engineering of a human cystathionine-γ-lyase for systemic (L)-Methionine depletion cancer therapy.Reversible growth arrest in simian virus 40-transformed human fibroblasts.Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells.Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour linesDecreased rates of methionine synthesis by methylene tetrahydrofolate reductase-deficient fibroblasts and lymphoblasts.Cobalamin binding and cobalamin-dependent enzyme activity in normal and mutant human fibroblasts.Absorption, plasma transport, and cellular retention of cobalamin analogues in the rabbit. Evidence for the existence of multiple mechanisms that prevent the absorption and tissue dissemination of naturally occurring cobalamin analogues.Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging.Reversion to methionine independence in simian virus 40-transformed human and malignant rat fibroblasts is associated with altered ploidy and altered properties of transformation.Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma.Targeting methionine auxotrophy in cancer: discovery & exploration.Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey.Sulphane sulphur in biological systems: a possible regulatory role.Is DNA methylation the new guardian of the genome?Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cells.Defects in auxiliary redox proteins lead to functional methionine synthase deficiency.Growth of methionine-dependent human prostate cancer (PC-3) is inhibited by ethionine combined with methionine starvation.Methylthioadenosine toxicity and metabolism to methionine in mammalian cells.Effect of methionine deprivation on methylation and synthesis of macromolecules.Metabolism of 5-methyltetrahydrofolate by rats bearing the Walker 256 carcinosarcoma.Investigations of tissue folates in normal and malignant tissues.Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma.Utilization of preformed and endogenously synthesized methionine by cells in tissue culture.A critical intracellular concentration of fully reduced non-methylated folate polyglutamates prevents macrocytosis and diminished growth rate of human cell line K562 in culture.L-methionase: a therapeutic enzyme to treat malignancies.Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model.Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention.Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase.The wayward methyl group and the cascade to cancer.Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT.Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: Decoy, trap and kill chTargeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.
P2860
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P2860
High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotrophic for methionine.
description
1976 nî lūn-bûn
@nan
1976 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1976 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1976年の論文
@ja
1976年論文
@yue
1976年論文
@zh-hant
1976年論文
@zh-hk
1976年論文
@zh-mo
1976年論文
@zh-tw
1976年论文
@wuu
name
High in vivo rates of methioni ...... ls auxotrophic for methionine.
@ast
High in vivo rates of methioni ...... ls auxotrophic for methionine.
@en
type
label
High in vivo rates of methioni ...... ls auxotrophic for methionine.
@ast
High in vivo rates of methioni ...... ls auxotrophic for methionine.
@en
prefLabel
High in vivo rates of methioni ...... ls auxotrophic for methionine.
@ast
High in vivo rates of methioni ...... ls auxotrophic for methionine.
@en
P2860
P356
P1476
High in vivo rates of methioni ...... ls auxotrophic for methionine.
@en
P2093
P2860
P304
P356
10.1073/PNAS.73.5.1523
P407
P577
1976-05-01T00:00:00Z