Reduced availability of endogenously synthesized methionine for S-adenosylmethionine formation in methionine-dependent cancer cells.
about
Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity.Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour linesMetabolic changes associated with methionine stress sensitivity in MDA-MB-468 breast cancer cells.Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging.Is DNA methylation the new guardian of the genome?Methylthioadenosine toxicity and metabolism to methionine in mammalian cells.Methionine metabolism and cancer.Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma.Utilization of preformed and endogenously synthesized methionine by cells in tissue culture.Combined methionine deprivation and chloroethylnitrosourea have time-dependent therapeutic synergy on melanoma tumors that NMR spectroscopy-based metabolomics explains by methionine and phospholipid metabolism reprogramming.Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model.Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention.Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase.The wayward methyl group and the cascade to cancer.Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: Decoy, trap and kill chMethionine metabolism and multiple sclerosis.Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models.Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model.
P2860
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P2860
Reduced availability of endogenously synthesized methionine for S-adenosylmethionine formation in methionine-dependent cancer cells.
description
1982 nî lūn-bûn
@nan
1982年の論文
@ja
1982年学术文章
@wuu
1982年学术文章
@zh-cn
1982年学术文章
@zh-hans
1982年学术文章
@zh-my
1982年学术文章
@zh-sg
1982年學術文章
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1982年學術文章
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1982年學術文章
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name
Reduced availability of endoge ...... ionine-dependent cancer cells.
@ast
Reduced availability of endoge ...... ionine-dependent cancer cells.
@en
type
label
Reduced availability of endoge ...... ionine-dependent cancer cells.
@ast
Reduced availability of endoge ...... ionine-dependent cancer cells.
@en
prefLabel
Reduced availability of endoge ...... ionine-dependent cancer cells.
@ast
Reduced availability of endoge ...... ionine-dependent cancer cells.
@en
P2093
P2860
P356
P1476
Reduced availability of endoge ...... ionine-dependent cancer cells.
@en
P2093
D W Coalson
J O Mecham
R M Hoffman
P2860
P304
P356
10.1073/PNAS.79.14.4248
P407
P577
1982-07-01T00:00:00Z