Reversion to methionine independence in simian virus 40-transformed human and malignant rat fibroblasts is associated with altered ploidy and altered properties of transformation.

Reversion to methionine independence in simian virus 40-transformed human and malignant rat fibroblasts is associated with altered ploidy and altered properties of transformation.

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http://www.wikidata.org/entity/Q37320996
Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity.Karyotype alteration generates the neoplastic phenotypes of SV40-infected human and rodent cellsReduced availability of endogenously synthesized methionine for S-adenosylmethionine formation in methionine-dependent cancer cells.De novo engineering of a human cystathionine-γ-lyase for systemic (L)-Methionine depletion cancer therapy.Reversible growth arrest in simian virus 40-transformed human fibroblasts.Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells.Metabolic changes associated with methionine stress sensitivity in MDA-MB-468 breast cancer cells.Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging.Targeting methionine auxotrophy in cancer: discovery & exploration.Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey.Is DNA methylation the new guardian of the genome?Utilization of preformed and endogenously synthesized methionine by cells in tissue culture.Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase.The wayward methyl group and the cascade to cancer.Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: Decoy, trap and kill ch
P2860

Reversion to methionine independence in simian virus 40-transformed human and malignant rat fibroblasts is associated with altered ploidy and altered properties of transformation.

Item
http://www.wikidata.org/entity/Q37320996
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1979
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Reversion to methionine indepe ...... properties of transformation.
@en
Reversion to methionine indepe ...... properties of transformation.
@nl
type
label
Reversion to methionine indepe ...... properties of transformation.
@en
Reversion to methionine indepe ...... properties of transformation.
@nl
prefLabel
Reversion to methionine indepe ...... properties of transformation.
@en
Reversion to methionine indepe ...... properties of transformation.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Reversion to methionine indepe ...... properties of transformation.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932