KSR is a scaffold required for activation of the ERK/MAPK module. - Wikidata - wikimedia - TriplyDB

KSR is a scaffold required for activation of the ERK/MAPK module.

KSR is a scaffold required for activation of the ERK/MAPK module.

http://www.wikidata.org/entity/Q35005553

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Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1 Role of phosphatidic acid in the coupling of the ERK cascade.A functional genomic analysis of cell morphology using RNA interference Engineering of Metabolic Pathways by Artificial Enzyme Channels CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling A CC-SAM, for coiled coil-sterile α motif, domain targets the scaffold KSR-1 to specific sites in the plasma membrane Scaffolds are 'active' regulators of signaling modules Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism.Pseudokinases: update on their functions and evaluation as new drug targets.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway hKSR-2, a vitamin D-regulated gene, inhibits apoptosis in arabinocytosine-treated HL60 leukemia cells Induction of differentiation of human leukemia cells by combinations of COX inhibitors and 1,25-dihydroxyvitamin D3 involves Raf1 but not Erk 1/2 signaling.Drosophila Raf's N terminus contains a novel conserved region and can contribute to torso RTK signaling.The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development.Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation GnRH signaling, the gonadotrope and endocrine control of fertility.The focal complex of epithelial cells provides a signalling platform for interleukin-8 induction in response to bacterial pathogens Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase Regulation of glucose homeostasis by KSR1 and MARK2.MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila.The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling.Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking.KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo.The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila.

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P2860

KSR is a scaffold required for activation of the ERK/MAPK module.

http://www.wikidata.org/entity/Q35005553

description

2002 nî lūn-bûn

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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի փետրվարին հրատարակված գիտական հոդված

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2002年の論文

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2002年学术文章

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2002年学术文章

@zh-cn

2002年学术文章

@zh-hans

2002年学术文章

@zh-my

2002年学术文章

@zh-sg

2002年學術文章

@yue

name

KSR is a scaffold required for activation of the ERK/MAPK module.

@ast

KSR is a scaffold required for activation of the ERK/MAPK module.

@en

type

label

KSR is a scaffold required for activation of the ERK/MAPK module.

@ast

KSR is a scaffold required for activation of the ERK/MAPK module.

@en

prefLabel

KSR is a scaffold required for activation of the ERK/MAPK module.

@ast

KSR is a scaffold required for activation of the ERK/MAPK module.

@en

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P1433

Genes & Development

P1476

KSR is a scaffold required for activation of the ERK/MAPK module.

@en

P2093

David Ferland-McCollough

http://www.w3.org/2001/XMLSchema#string

François Roy

http://www.w3.org/2001/XMLSchema#string

Gino Laberge

http://www.w3.org/2001/XMLSchema#string

Marc Therrien

http://www.w3.org/2001/XMLSchema#string

Mélanie Douziech

http://www.w3.org/2001/XMLSchema#string

P2860

The JIP group of mitogen-activated protein kinase scaffold proteins

KSR, a novel protein kinase required for RAS signal transduction

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

Functional analysis of CNK in RAS signaling

Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae.

Signaling through scaffold, anchoring, and adaptor proteins

Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

P304

427-438

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scholarly article

P356

10.1101/GAD.962902

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P433

4

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P478

16

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2002-02-01T00:00:00Z

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11511780

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11850406

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155344

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