Dual-specificity phosphatases as targets for antineoplastic agents.
about
Targeting protein serine/threonine phosphatases for drug developmentA natural love of natural products.Compound library development guided by protein structure similarity clustering and natural product structureBioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach.Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: insights from structure-based modeling and high throughput screening.Targeting PTPs with small molecule inhibitors in cancer treatmentDevelopment of antiproliferative phenylmaleimides that activate the unfolded protein response.Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core StructureProtein tyrosine phosphatases as potential therapeutic targets.Specific targeting of caspase-9/PP2A interaction as potential new anti-cancer therapyDiscovery of protein phosphatase inhibitor classes by biology-oriented synthesisInhibition of CDC25B phosphatase through disruption of protein-protein interactionRecent advances towards identification of new drug targets for Mycobacterium tuberculosis.Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling.Mechanism of Cdc25B phosphatase with the small molecule substrate p-nitrophenyl phosphate from QM/MM-MFEP calculations.Synthetic strategies toward carbocyclic purine-pyrimidine hybrid nucleosides.Targeting cell division cycle 25 homolog B to regulate influenza virus replication.Is Cdc25 a druggable target?Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.Remote hot spots mediate protein substrate recognition for the Cdc25 phosphatase.Inhibitors of Cdc25 phosphatases as anticancer agents: a patent review.Mimicking/extracting structure and functions of natural products: synthetic approaches that address unexplored needs in chemical biology.Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options.MPL1, a novel phosphatase with leucine-rich repeats, is essential for proper ERK2 phosphorylation and cell motilityAnthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb.Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin.Screening the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2 kinase.Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure.Prognostic significance of high phosphatase of regenerating liver-3 expression in patients with gastric cancer who underwent curative gastrectomy.Synthesis and biological evaluation of caulibugulones A-E.The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors.Molecular network and chromosomal clustering of genes involved in synaptic plasticity in the hippocampus.CDC25A-inhibitory RE derivatives bind to pocket adjacent to the catalytic site.ϵ-Polylysine-Capped Mesoporous Silica Nanoparticles as Carrier of the C9h Peptide to Induce Apoptosis in Cancer Cells.Expression of Phosphatase Regenerating Liver-1 in Esophageal Squamous Cell Carcinoma Associated with Metastasis
P2860
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P2860
Dual-specificity phosphatases as targets for antineoplastic agents.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Dual-specificity phosphatases as targets for antineoplastic agents.
@ast
Dual-specificity phosphatases as targets for antineoplastic agents.
@en
type
label
Dual-specificity phosphatases as targets for antineoplastic agents.
@ast
Dual-specificity phosphatases as targets for antineoplastic agents.
@en
prefLabel
Dual-specificity phosphatases as targets for antineoplastic agents.
@ast
Dual-specificity phosphatases as targets for antineoplastic agents.
@en
P2860
P356
P1476
Dual-specificity phosphatases as targets for antineoplastic agents.
@en
P2093
Alexander P Ducruet
Michael A Lyon
P2860
P2888
P304
P356
10.1038/NRD963
P577
2002-12-01T00:00:00Z