The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases
about
High-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallographyBiological phosphoryl-transfer reactions: understanding mechanism and catalysisBeyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteinsAlkaline phosphatase mono- and diesterase reactions: comparative transition state analysisUroporphyrinogen decarboxylation as a benchmark for the catalytic proficiency of enzymesTesting Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion HoleImpaired Acid Catalysis by Mutation of a Protein Loop Hinge Residue in a YopH Mutant Revealed by Crystal StructuresDissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion holeAtomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by Formula rather than by phosphoranesInsights into the Reaction of Protein-tyrosine Phosphatase 1B: CRYSTAL STRUCTURES FOR TRANSITION STATE ANALOGS OF BOTH CATALYTIC STEPSStructural Insights into the Recovery of Aldolase Activity inN-Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with γ-Thialysine by Using a Chemical Mutagenesis StrategyStructure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7Near attack conformers dominate -phosphoglucomutase complexes where geometry and charge distribution reflect those of substrateGround state destabilization by anionic nucleophiles contributes to the activity of phosphoryl transfer enzymesThe molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1BPrimordial chemistry and enzyme evolution in a hot environmentConservative tryptophan mutants of the protein tyrosine phosphatase YopH exhibit impaired WPD-loop function and crystallize with divanadate esters in their active sitesCatalytic DNA with phosphatase activityα-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction.Phosphate monoester hydrolysis in cyclohexane.Enhancement of the rate of pyrophosphate hydrolysis by nonenzymatic catalysts and by inorganic pyrophosphatase.Phosphoinositide phosphatases in cell biology and disease.The hydrolysis of phosphate diesters in cyclohexane and acetoneA persistent pesticide residue and the unusual catalytic proficiency of a dehalogenating enzymeQM/MM analysis suggests that Alkaline Phosphatase (AP) and nucleotide pyrophosphatase/phosphodiesterase slightly tighten the transition state for phosphate diester hydrolysis relative to solution: implication for catalytic promiscuity in the AP supeMassive thermal acceleration of the emergence of primordial chemistry, the incidence of spontaneous mutation, and the evolution of enzymes.Impact of temperature on the time required for the establishment of primordial biochemistry, and for the evolution of enzymes.The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNAResolving apparent conflicts between theoretical and experimental models of phosphate monoester hydrolysisA Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C).Monoalkyl sulfates as alkylating agents in water, alkylsulfatase rate enhancements, and the "energy-rich" nature of sulfate half-esters.Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effectsMechanisms and free energies of enzymatic reactions.Promiscuity in the Enzymatic Catalysis of Phosphate and Sulfate Transfer.The Competing Mechanisms of Phosphate Monoester Dianion HydrolysisExceptionally large entropy contributions enable the high rates of GTP hydrolysis on the ribosome.Extending enzyme molecular recognition with an expanded amino acid alphabet.A modified QM/MM Hamiltonian with the Self-Consistent-Charge Density-Functional-Tight-Binding Theory for highly charged QM regions.Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems.
P2860
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P2860
The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The rate of hydrolysis of phos ...... tein and inositol phosphatases
@ast
The rate of hydrolysis of phos ...... tein and inositol phosphatases
@en
type
label
The rate of hydrolysis of phos ...... tein and inositol phosphatases
@ast
The rate of hydrolysis of phos ...... tein and inositol phosphatases
@en
prefLabel
The rate of hydrolysis of phos ...... tein and inositol phosphatases
@ast
The rate of hydrolysis of phos ...... tein and inositol phosphatases
@en
P2860
P356
P1476
The rate of hydrolysis of phos ...... tein and inositol phosphatases
@en
P2093
Chetan Lad
Richard Wolfenden
P2860
P304
P356
10.1073/PNAS.0631607100
P407
P577
2003-04-29T00:00:00Z