about
Amino-functionalized DNA: the properties of C5-amino-alkyl substituted 2'-deoxyuridines and their application in DNA triplex formationAtomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by Formula rather than by phosphoranesThe alkaline hydrolysis of sulfonate esters: challenges in interpreting experimental and theoretical dataThe time required for water attack at the phosphorus atom of simple phosphodiesters and of DNAPhotocatalytic nanolithography of self-assembled monolayers and proteinsFabrication of molecular nanopatterns at aluminium oxide surfaces by nanoshaving of self-assembled monolayers of alkylphosphonates.The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatasesResolving apparent conflicts between theoretical and experimental models of phosphate monoester hydrolysisA Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.Models for biological phosphoryl transfer.The Competing Mechanisms of Phosphate Monoester Dianion HydrolysisMechanistic study of protein phosphatase-1 (PP1), a catalytically promiscuous enzymeMechanism and transition state structure of aryl methylphosphonate esters doubly coordinated to a dinuclear cobalt(III) center.Oligonucleotide based artificial nuclease (OBAN) systems. Bulge size dependence and positioning of catalytic group in cleavage of RNA-bulges.Catalytic zinc complexes for phosphate diester hydrolysis.Three metal ions participate in the reaction catalyzed by T5 flap endonuclease.Brønsted analysis and rate-limiting steps for the T5 flap endonuclease catalyzed hydrolysis of exonucleolytic substrates.MgF(3)(-) and alpha-galactose 1-phosphate in the active site of beta-phosphoglucomutase form a transition state analogue of phosphoryl transfer.Intramolecular general base catalysis in the hydrolysis of a phosphate diester. Calculational guidance to a choice of mechanism.An altered mechanism of hydrolysis for a metal-complexed phosphate diester.Cooperative binding at lipid bilayer membrane surfaces.Altered mechanisms of reactions of phosphate esters bridging a dinuclear metal center.Kinetic analysis of beta-phosphoglucomutase and its inhibition by magnesium fluoride.Dineopentyl phosphate hydrolysis: evidence for stepwise water attack.Dinuclear Zn(II) complex promotes cleavage and isomerization of 2-hydroxypropyl alkyl phosphates by a common cyclic phosphate intermediate.Cleavage and isomerization of UpU promoted by dinuclear metal ion complexes.Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.Triggered Release from Lipid Bilayer Vesicles by an Artificial Transmembrane Signal Transduction System.Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1.Recognition-Controlled Membrane Translocation for Signal Transduction across Lipid Bilayers.Controlled membrane translocation provides a mechanism for signal transduction and amplification.Simulating the reactions of substituted pyridinio-N-phosphonates with pyridine as a model for biological phosphoryl transfer.Catalysis in a Cationic Coordination Cage Using a Cavity-Bound Guest and Surface-Bound Anions: Inhibition, Activation, and Autocatalysis.Enhancing Phosphate Diester Cleavage by a Zinc Complex through Controlling Nucleophile Coordination.'Rough guide' evanescent wave optrode for colorimetric metalloporphyrine sensors.Double-network hydrogels improve pH-switchable adhesion.Activating water: important effects of non-leaving groups on the hydrolysis of phosphate triesters.Computer simulations of the catalytic mechanism of wild-type and mutant β-phosphoglucomutase.Magnesium Ion Catalyzed ATP HydrolysisPhosphate ester analogues as probes for understanding enzyme catalysed phosphoryl transfer
P50
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P50
description
onderzoeker
@nl
researcher, ORCID id # 0000-0002-4457-4220
@en
name
Nicholas H Williams
@ast
Nicholas H Williams
@en
Nicholas H Williams
@es
Nicholas H Williams
@nl
type
label
Nicholas H Williams
@ast
Nicholas H Williams
@en
Nicholas H Williams
@es
Nicholas H Williams
@nl
prefLabel
Nicholas H Williams
@ast
Nicholas H Williams
@en
Nicholas H Williams
@es
Nicholas H Williams
@nl
P106
P1153
57190012664
7402772190
P21
P31
P496
0000-0002-4457-4220