BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability.
about
Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaksEnhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cellsImpaired DNA replication within progenitor cell pools promotes leukemogenesis.Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers.BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells.Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias.Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation.Intracellular mRNA cleavage by 3' tRNase under the direction of 2'-O-methyl RNA heptamers.Leukemia stem cells in a genetically defined murine model of blast-crisis CML.ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia.Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemiaThe role of aberrant transcription factor in the progression of chronic myeloid leukemia.Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release.Recent advances in quantitative chimerism analysis.DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy.Imatinib increases cytotoxicity of melphalan and their combination allows an efficient killing of chronic myeloid leukemia cells.Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase Cdelta.BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance.Modeling the influence of stromal microenvironment in the selection of ENU-induced BCR-ABL1 mutants by tyrosine kinase inhibitors.Survival outcomes for clonal evolution in chronic myeloid leukemia patients on second generation tyrosine kinase inhibitor therapy.An emerging role for nuclear RNA-mediated responses to genotoxic stress.STAT5 signaling is required for the efficient induction and maintenance of CML in mice.ETV6/RUNX1 induces reactive oxygen species and drives the accumulation of DNA damage in B cells.Do cells need CDK2 and ... Bcr-Abl?HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.Chronic exposure to low dose of bisphenol A impacts on the first round of spermatogenesis via SIRT1 modulation.Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia
P2860
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P2860
BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
BCR/ABL regulates response to ...... nt and in genomic instability.
@ast
BCR/ABL regulates response to ...... nt and in genomic instability.
@en
type
label
BCR/ABL regulates response to ...... nt and in genomic instability.
@ast
BCR/ABL regulates response to ...... nt and in genomic instability.
@en
prefLabel
BCR/ABL regulates response to ...... nt and in genomic instability.
@ast
BCR/ABL regulates response to ...... nt and in genomic instability.
@en
P2860
P356
P1433
P1476
BCR/ABL regulates response to ...... nt and in genomic instability.
@en
P2093
Tomasz Skorski
P2860
P2888
P304
P356
10.1038/SJ.ONC.1206087
P407
P577
2002-12-01T00:00:00Z
P6179
1037121446